Department of Obstetrics and Gynecology, Neonatal and Maternal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Med Case Rep. 2021 May 28;15(1):310. doi: 10.1186/s13256-021-02698-5.
The outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health emergency by the World Health Organization on January 30, 2020. The results of recent studies have suggested that neonates may present symptoms of COVID-19. Although the presentation of the disease in neonates is known to vary, only a limited number of studies have investigated newborns infected with COVID-19.
This study presents two Asian cases of newborns with COVID-19. Maternal-fetal or postnatal transmission was suggested based on the simultaneity of maternal infection. Chest radiography in one of the neonates showed severe lung involvement. Despite support and resuscitation attempts, the poor clinical condition of the neonate led to his death. However, the two mothers and one of the neonates were discharged from the hospital in good general condition.
The neonates had worse clinical conditions than the mothers, and the intensity of pneumonia and level of lung involvement in the newborns were not associated with the stage and severity of the disease in the mothers with COVID-19.
由新型严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 爆发，世界卫生组织于 2020 年 1 月 30 日宣布为公共卫生紧急事件。最近的研究结果表明，新生儿可能出现 COVID-19 症状。尽管已知新生儿疾病的表现有所不同，但只有少数研究调查了感染 COVID-19 的新生儿。
本研究介绍了两例亚洲 COVID-19 新生儿病例。基于母体感染的同时性，提示存在母婴-胎儿或产后传播。其中一名新生儿的胸部 X 光片显示严重肺部受累。尽管进行了支持和复苏尝试，但新生儿的病情不佳导致其死亡。然而，两名母亲和一名新生儿情况良好，从医院出院。
新生儿的临床状况比母亲差，且新生儿的肺炎严重程度和肺部受累程度与 COVID-19 母亲的疾病阶段和严重程度无关。
