Duprez Joan, Houvenaghel Jean-François, Argaud Soizic, Naudet Florian, Robert Gabriel, Drapier Dominique, Vérin Marc, Sauleau Paul
"Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France.
"Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; Department of Neurology, Rennes University Hospital, Rue Henri Le Guilloux, 35033 Rennes, France.
Neuropsychologia. 2017 Jan 27;95:250-258. doi: 10.1016/j.neuropsychologia.2016.12.027. Epub 2016 Dec 28.
The effects of Parkinson's disease (PD) on the dynamics of impulsive action selection and suppression have recently been studied using distributional analyses, but with mixed results, especially for selection. Furthermore, some authors have suggested that impulsivity, regarded as a personality trait, shares common features with behavioral tasks' measures. The current study was designed to clarify the impact of PD on impulsive action selection and suppression, and investigate the link between cognitive action control and self-reported impulsivity. We administered an oculomotor version of the Simon task to 32 patients with PD and 32 matched healthy controls (HC), and conducted distributional analyses in accordance with the activation-suppression model. Patients and HC also filled out the Barratt Impulsiveness Scale (BIS) questionnaire. Results showed that patients with PD were faster overall and exhibited a greater congruence effect than HC. They also displayed enhanced impulsive action selection. By contrast, the suppression of impulsive responses was similar across both groups. Furthermore, patients had higher impulsivity scores, which were correlated with higher impulsive action selection and higher suppression. Our study yielded two interesting findings. First, PD resulted in a higher number of fast errors. The activation-suppression model suggests that patients with PD are more susceptible to the impulsive action selection induced by the irrelevant stimulus dimension. Second, impulsive action selection and suppression were both associated with trait impulsivity, as measured by the BIS, indicating that these two aspects of impulsivity share common features.
最近，研究人员使用分布分析方法研究了帕金森病（PD）对冲动行为选择和抑制动态的影响，但结果不一，尤其是在选择方面。此外，一些作者认为，作为一种人格特质的冲动性与行为任务的测量方法有共同特征。本研究旨在阐明PD对冲动行为选择和抑制的影响，并探讨认知行为控制与自我报告的冲动性之间的联系。我们对32名PD患者和32名匹配的健康对照者（HC）进行了眼动版的西蒙任务，并根据激活-抑制模型进行了分布分析。患者和HC还填写了巴拉特冲动性量表（BIS）问卷。结果显示，PD患者总体上反应更快，比HC表现出更大的一致性效应。他们还表现出增强的冲动行为选择。相比之下，两组对冲动反应的抑制相似。此外，患者的冲动性得分更高，这与更高的冲动行为选择和更高的抑制相关。我们的研究有两个有趣的发现。第一，PD导致快速错误的数量增加。激活-抑制模型表明，PD患者更容易受到无关刺激维度诱导的冲动行为选择的影响。第二，冲动行为选择和抑制都与BIS测量的特质冲动性相关，这表明冲动性的这两个方面有共同特征。
