Kryzhanovskii S A, Kozhevnikova L M, Vititnova M B, Efimova A O, Stolyaruk V N, Tsorin I B
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Bull Exp Biol Med. 2021 May;171(1):41-44. doi: 10.1007/s10517-021-05168-6. Epub 2021 May 29.
The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy contributes to normalization of the expression of mRNA of genes of regulatory proteins СаМ (p=0.00001), Ерас1 (p=0.021), and Ерас2 (p=0.018) and receptors RyR2 (p=0.0031) and IP3R2 (p=0.006) in the myocardium of the myocardium of the left ventricle that is enhanced in control animals (p<0.05). These changes were accompanied by echocardiographically documented decrease in the degree of left ventricle remodeling and improvement of its inotropic function.
我们使用自行构建的酒精性心肌病大鼠转化模型，研究了法博莫唑心脏保护作用的分子机制。结果显示，给患有酒精性心肌病的动物腹腔注射法博莫唑（15毫克/千克），持续28天，有助于使左心室心肌中调节蛋白CaM（p = 0.00001）、Eras1（p = 0.021）和Eras2（p = 0.018）以及受体RyR2（p = 0.0031）和IP3R2（p = 0.006）的基因mRNA表达正常化，而在对照动物中这些基因的表达增强（p < 0.05）。这些变化伴随着超声心动图记录的左心室重塑程度降低及其变力功能改善。
