Department of Biomedical Sciences, University of Padova, Neuroscience Institute of the National Research Council, Italy.
Biofactors. 2011 May-Jun;37(3):219-27. doi: 10.1002/biof.160. Epub 2011 Jun 14.
Mitochondrial Ca(2+) homeostasis is an important component of the calcium-mediated cellular response to extracellular stimuli. It controls key organelle functions, such as aerobic metabolism and the induction of apoptotic cell death, and shapes the spatiotemporal pattern of the cytosolic [Ca(2+)] increase. We here summarize both the main roles of Ca(2+) signals within mitochondria and the emerging molecular information that is starting to unravel the composition of the signaling apparatus and reveal potential pharmacological targets in this process of utmost pathophysiological relevance.
线粒体 Ca(2+) 稳态是细胞对外界刺激产生钙介导反应的重要组成部分。它控制着关键细胞器的功能，如有氧代谢和凋亡细胞死亡的诱导，并塑造了细胞质 [Ca(2+)] 增加的时空模式。我们在这里总结了 Ca(2+) 信号在线粒体中的主要作用，以及开始揭示信号装置组成并揭示这一过程中潜在药理靶点的新兴分子信息，这一过程具有至关重要的病理生理学意义。
