Dudas Gytis, Huber Greg, Wilkinson Michael, Yllanes David
Gothenburg Global Biodiversity Centre, Carl Skottsbergs Gata 22B, 413 19 Gothenburg, Sweden.
Chan Zuckerberg Biohub, 499 Illinois Street, San Francisco, CA 94158, USA.
Virus Evol. 2021 Apr 19;7(1):veab038. doi: 10.1093/ve/veab038. eCollection 2021 Jan.
Double synonyms in the genetic code can be used as a tool to test competing hypotheses regarding ambigrammatic narnavirus genomes. Applying the analysis to recent observations of and ambigrammatic viruses indicates that the open reading frame on the complementary strand of the segment coding for RNA-dependent RNA polymerase does code for a functional protein. has been shown to possess a second segment, also ambigrammatic, termed 'Robin'. We find a comparable segment for , a moderately diverged relative of . Our analysis of Robin polymorphisms suggests that its reverse open reading frame also does not code for a functional protein. We make a hypothesis about its role.
遗传密码中的双重同义词可作为一种工具，用于检验关于双义性纳罗病毒基因组的相互竞争的假说。将该分析应用于最近对双义性病毒的观察结果表明，编码RNA依赖性RNA聚合酶的片段互补链上的开放阅读框确实编码一种功能性蛋白质。已证明[病毒名称1]拥有第二个片段，也是双义性的，称为“罗宾”。我们为[病毒名称2]找到了一个类似的片段，它是[病毒名称1]的中度分化的亲属。我们对“罗宾”多态性的分析表明，其反向开放阅读框也不编码功能性蛋白质。我们对其作用提出了一个假说。
