Jia Xiaonan, Yin Yiqian, Chen Yiwen, Mao Lingxiang
Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Front Cell Infect Microbiol. 2021 May 13;11:671625. doi: 10.3389/fcimb.2021.671625. eCollection 2021.
Exosomes are membrane-bound vesicles of endocytic origin, secreted into the extracellular milieu, in which various biological components such as proteins, nucleic acids, and lipids reside. A variety of external stimuli can regulate the formation and secretion of exosomes, including viruses. Viruses have evolved clever strategies to establish effective infections by employing exosomes to cloak their viral genomes and gain entry into uninfected cells. While most recent exosomal studies have focused on clarifying the effect of these bioactive vesicles on viral infection, the mechanisms by which the virus regulates exosomes are still unclear and deserve further attention. This article is devoted to studying how viral components regulate exosomes biogenesis, composition, and secretion.
外泌体是内吞起源的膜结合囊泡，分泌到细胞外环境中，其中存在蛋白质、核酸和脂质等各种生物成分。多种外部刺激可调节外泌体的形成和分泌，包括病毒。病毒已经进化出巧妙的策略，通过利用外泌体包裹其病毒基因组并进入未感染细胞来建立有效的感染。虽然最近大多数外泌体研究都集中在阐明这些生物活性囊泡对病毒感染的影响，但病毒调节外泌体的机制仍不清楚，值得进一步关注。本文致力于研究病毒成分如何调节外泌体的生物发生、组成和分泌。
