Waqar Zainulabedin, Avula Sindhu, Shah Jay, Ali Syed Sohail
Department of Internal Medicine, Mercy St. Vincent Medical Center, Toledo, OH 43608, USA.
Department of Cardiology, Mercy St Vincent Medical Center, Toledo, OH 43608, USA.
J Endocr Soc. 2021 Mar 11;5(6):bvab040. doi: 10.1210/jendso/bvab040. eCollection 2021 Jun 1.
Thyroid storm can present as a multitude of symptoms, the most significant being cardiovascular (CV). It is associated with various manifestations such as cardiac arrhythmia, heart failure, and ischemia. However, the frequencies of events and characteristics associated with patients that experience these events are not known.
Study cohort was derived from the National Inpatient Sample database from January 2012 to September 2015. Total hospitalizations of thyroid storm were identified using appropriate ICD-9 diagnostic codes. The analysis was performed using SAS.
To better understand the frequency and characteristics CV occurrences associated with thyroid storm, through a retrospective analysis of thyroid storm hospital admissions.
The study cohort was derived from the National Inpatient Sample database from January 2012 to September 2015.
Total hospitalizations of thyroid storm were identified using International Classification of Diseases (ICD)-9 diagnostic codes. The analysis was performed using Statistical Analysis System (SAS).
A total of 6380 adult hospitalizations were included in the final analysis, which includes 3895 hospitalizations with CV events (CEs). Most frequently associated CEs were arrhythmia (N = 3770) followed by acute heart failure (N = 555) and ischemic events (N = 150). Inpatient mortality was significantly higher in patients with CEs compared with those without CEs (3.5% vs 0.2%, < 0.005). The median length of stay was also higher in patients with CEs compared with those without CEs (4 days vs 3 days, < 0.0005). Atrial fibrillation was the most common arrhythmia type, followed by nonspecified tachycardia.
In patients who were hospitalized due to thyroid storm and associated CEs significantly increased in-hospital mortality, length of stay, and cost. Patients with obesity, alcohol abuse, chronic liver disease, and COPD were more likely to have CEs. Patients with CV complications were at higher risk for mortality. In-hospital mortality increased with ischemic events and acute heart failure. Further evaluation is needed to further classify the type of arrhythmias and associated mortality.
甲状腺危象可表现为多种症状，其中最显著的是心血管方面的症状。它与多种表现相关，如心律失常、心力衰竭和缺血。然而，经历这些事件的患者相关事件的发生频率和特征尚不清楚。
研究队列来自2012年1月至2015年9月的国家住院患者样本数据库。使用适当的ICD-9诊断代码识别甲状腺危象的全部住院病例。分析使用SAS进行。
通过对甲状腺危象住院患者的回顾性分析，更好地了解与甲状腺危象相关的心血管事件的发生频率和特征。
研究队列来自2012年1月至2015年9月的国家住院患者样本数据库。
使用国际疾病分类（ICD）-9诊断代码识别甲状腺危象的全部住院病例。分析使用统计分析系统（SAS）进行。
最终分析共纳入6380例成人住院病例，其中包括3895例发生心血管事件（CEs）的住院病例。最常相关的心血管事件是心律失常（N = 3770），其次是急性心力衰竭（N = 555）和缺血事件（N = 150）。发生心血管事件的患者住院死亡率显著高于未发生心血管事件的患者（3.5%对0.2%，P < 0.005）。发生心血管事件的患者中位住院时间也高于未发生心血管事件的患者（4天对3天，P < 0.0005）。房颤是最常见的心律失常类型，其次是未特定的心动过速。
因甲状腺危象住院且伴有心血管事件的患者，住院死亡率、住院时间和费用显著增加。肥胖、酗酒、慢性肝病和慢性阻塞性肺疾病患者更易发生心血管事件。发生心血管并发症的患者死亡风险更高。缺血事件和急性心力衰竭会使住院死亡率增加。需要进一步评估以进一步分类心律失常的类型及其相关死亡率。
