Institute of Physiology, Medical University of Innsbruck, Austria.
Institute of Physiology, Medical University of Innsbruck, Austria.
Cytokine. 2021 Aug;144:155582. doi: 10.1016/j.cyto.2021.155582. Epub 2021 May 29.
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial and destructive potentials. It can exert opposing actions triggering either neuron survival after injury or causing neurodegeneration and cell death in neurodegenerative or neuropathic disorders. Importantly, neurons respond differently to IL-6 and this critically depends on their environment and whether they are located in the peripheral or the central nervous system. In addition to its hub regulator role in inflammation, IL-6 is recently emerging as an important regulator of neuron function in health and disease, offering exciting possibilities for more mechanistic insight into the pathogenesis of mental, neurodegenerative and pain disorders and for developing novel therapies for diseases with neuroimmune and neurogenic pathogenic components.
多功能细胞因子白细胞介素-6（IL-6）作为一种具有双重作用的分子正逐渐受到关注，它既能促进神经元存活，又能在神经退行性或神经病理性疾病中导致神经变性和细胞死亡。重要的是，神经元对 IL-6 的反应不同，这主要取决于它们所处的环境以及它们位于外周神经系统还是中枢神经系统。除了在炎症中作为枢纽调节因子的作用外，IL-6 最近也被认为是健康和疾病中神经元功能的重要调节因子，为更深入地了解精神、神经退行性和疼痛障碍的发病机制以及开发具有神经免疫和神经源性致病成分的疾病的新型治疗方法提供了令人兴奋的可能性。
