Lampson L A
Children's Cancer Research Center, Children's Hospital of Philadelphia, PA 19104.
Prog Clin Biol Res. 1988;271:409-20.
In these studies, strong HLA-A,B,C or b2-m expression was not detected in any stage of development of normal neurons. These included regenerating cells of the olfactory epithelium, developing neural tissue in the mouse embryo, and normal adult brain. Nor was an obligatory role for HLA-A,B,C or b2-m revealed by in vitro analysis of a growing neuroblastoma cell line.
在这些研究中，在正常神经元发育的任何阶段均未检测到强HLA - A、B、C或β2 -微球蛋白表达。这些包括嗅觉上皮的再生细胞、小鼠胚胎中发育的神经组织以及正常成体脑。对一个正在生长的神经母细胞瘤细胞系的体外分析也未揭示HLA - A、B、C或β2 -微球蛋白的必然作用。
