Greek Association of Alzheimer's Disease and Related Disorders, Thessaloniki, Greece.
Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Geriatr Psychiatry Neurol. 2022 Jul;35(4):512-526. doi: 10.1177/08919887211016057. Epub 2021 Jun 1.
This study assesses the effectiveness of a multicomponent Longitudinal Cognitive Training (CT) program plus physical exercise (PE) for people with Mild Cognitive Impairment (MCI). 155 people with MCI, completed a 3 years (3Y) CT+PE, whilst 133 were control. Neuropsychological assessment was performed at baseline and 3 years later, whilst CT+PE had additional annual assessments. According to the results, the 3Y CT+PE outperformed control in cognitive abilities ( < 0.002), and Activities of Daily Living (ADL) ( < 0.001), stabilized their functional performances between 1st and 2nd year, but worsened in working and verbal memory between 2nd and 3 rd year ( < 0.002). Control deteriorated in cognitive functions ( < 0.001) and ADL ( < 0.001) after 3 years, whilst 1.33% of the experimental and 13.53% of the control group progressed to dementia ( < 0.001). Longitudinal CT+PE improves cognitive performance and ADL in MCI and delay the progression to dementia.
本研究评估了多组分纵向认知训练（CT）加身体锻炼（PE）对轻度认知障碍（MCI）患者的疗效。155 名 MCI 患者完成了 3 年（3Y）的 CT+PE，而 133 名患者为对照组。在基线和 3 年后进行了神经心理学评估，而 CT+PE 则进行了额外的年度评估。结果显示，3Y CT+PE 在认知能力（<0.002）和日常生活活动能力（ADL）（<0.001）方面优于对照组，并在第 1 年和第 2 年之间稳定了他们的功能表现，但在第 2 年和第 3 年之间在工作记忆和言语记忆方面恶化（<0.002）。对照组在 3 年后认知功能（<0.001）和 ADL（<0.001）下降，而实验组有 1.33%和对照组有 13.53%的患者进展为痴呆（<0.001）。纵向 CT+PE 可改善 MCI 患者的认知表现和 ADL，并延缓向痴呆的进展。
