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丹麦 2010-2019 年激素避孕药具的使用情况。

Hormonal contraceptive use in Denmark 2010-2019.

出版信息

Dan Med J. 2021 May 28;68(6):A08200599.

Abstract

INTRODUCTION

Hormonal contraception (HC) celebrates its 60th anniversary this year. Thanks to thousands of scientific studies on these products, we now have solid knowledge about the short- and long-term effects and also the adverse effects of different contraceptive types. The aim of this study was to analyse trends in the use of different types of HC through the latest decade in different age groups of Danish women and to study reasons for any changes.

METHODS

Individual-level HC sale statistics were provided from the National Registry of Medicinal Products. All statistics were stated as defined daily doses per 1,000 women per day. Absolute numbers and distributions among users were calculated.

RESULTS

The overall use of HC was stable in women from 15 to 25 years, decreased among women aged 25-34 years and increased among women aged 35 years or more. On average, an increase from 35% to 39% was recorded. Across all age groups, the use of second-generation combined oral contraceptives (COC) has almost completely replaced the use of third- and fourth-generation pills, and from the age of 20 years of age, the use of COC has decreased contrasting a steep increase in use of the hormone-intrauterine device (IUD). The magnitude of this shift increased with increasing age.

CONCLUSIONS

Whereas the overall use of hormonal contraception has increased over the latest decade from 35% to 39% among all women aged 15-49 years, hormone-IUDs have increasingly replaced COCs so that they are now dominating among women aged 30 years or more. These changes are expected to have decreased venous thrombosis and menorrhagic complaints in young women substantially.

FUNDING

Expenses were covered by Department of Gynaecology, Rigshospitalet.

TRIAL REGISTRATION

The Danish Data Protection Agency (R. no. 2015-41-4481).

摘要

引言

今年,激素避孕(HC)迎来了 60 周年纪念。得益于数千项关于这些产品的科学研究,我们现在对短期和长期影响以及不同避孕类型的不良反应有了确凿的认识。本研究旨在分析丹麦不同年龄段女性在过去十年中使用不同类型 HC 的趋势,并研究任何变化的原因。

方法

国家药品登记处提供了个人层面的 HC 销售统计数据。所有统计数据均以每千名女性每天的定义日剂量表示。计算了使用者的绝对数量和分布情况。

结果

15-25 岁女性的 HC 总体使用率保持稳定,25-34 岁女性的使用率下降,35 岁及以上女性的使用率上升。平均而言,记录到从 35%增加到 39%。在所有年龄组中,第二代复方口服避孕药(COC)的使用几乎完全取代了第三代和第四代药丸,并且从 20 岁开始,COC 的使用减少,而激素宫内节育器(IUD)的使用急剧增加。这种转变的幅度随着年龄的增加而增加。

结论

在过去十年中,所有 15-49 岁女性的激素避孕总使用率从 35%增加到 39%,而激素 IUD 的使用越来越多,以至于它们现在在 30 岁及以上的女性中占据主导地位。这些变化预计会大大减少年轻女性的静脉血栓形成和月经过多的投诉。

经费

由哥本哈根大学医院妇产科承担。

试验注册

丹麦数据保护局(登记号:2015-41-4481)。

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