Department of Experimental Psychology, University of Oxford.
Behav Neurosci. 2021 Apr;135(2):165-173. doi: 10.1037/bne0000442.
The orbitofrontal cortex (OFC) plays a critical role in the flexible control of behaviors and has been the focus of increasing research interest. However, there have been a number of controversies around the exact theoretical role of the OFC. One potential source of these issues is the comparison of evidence from different studies, particularly across species, which focus on different specific sub-regions within the OFC. Furthermore, there is emerging evidence that there may be functional diversity across the OFC which may account for these theoretical differences. Therefore, in this review we consider evidence supporting functional heterogeneity within the OFC and how it relates to underlying anatomical heterogeneity. We highlight the importance of anatomical and functional distinctions within the traditionally defined OFC subregions across the medial-lateral axis, which are often not differentiated for practical and historical reasons. We then consider emerging evidence of even finer-grained distinctions within these defined subregions along the anterior-posterior axis. These fine-grained anatomical considerations reveal a pattern of dissociable, but often complementary functions within the OFC. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
眶额皮层（OFC）在行为的灵活控制中起着关键作用，越来越受到研究的关注。然而，关于 OFC 的确切理论作用存在许多争议。这些问题的一个潜在来源是对来自不同研究的证据的比较，特别是在跨物种的情况下，这些研究集中在 OFC 内的不同特定亚区。此外，有新的证据表明，OFC 可能存在功能多样性，这可能解释了这些理论差异。因此，在这篇综述中，我们考虑了支持 OFC 内功能异质性的证据，以及它与潜在的解剖学异质性的关系。我们强调了在传统定义的 OFC 亚区的内侧-外侧轴上进行解剖学和功能区分的重要性，由于实际和历史原因，这些区分通常没有得到区分。然后，我们考虑了在这些定义的亚区内沿着前后轴进行更精细区分的新出现的证据。这些精细的解剖学考虑揭示了 OFC 内分离但通常互补的功能模式。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
