Lahiri Debrupa, Ghosh Sanat, Agarwal Arvind
Plasma Forming Laboratory, Nanomechanics and Nanotribology Laboratory, Mechanical and Materials Engineering, 10555 West Flagler Street, EC 3464, Florida International University, Miami, FL 33174, USA.
Plasma Forming Laboratory, Nanomechanics and Nanotribology Laboratory, Mechanical and Materials Engineering, 10555 West Flagler Street, EC 3464, Florida International University, Miami, FL 33174, USA; Metallurgical Engineering and Material Science, Indian Institute of Technology-Bombay, Powai, Mumbai, India.
Mater Sci Eng C Mater Biol Appl. 2012 Oct 1;32(7):1727-1758. doi: 10.1016/j.msec.2012.05.010. Epub 2012 May 16.
Application of hydroxyapatite (HA) in orthopedic implants suffers from its low fracture toughness and poor wear resistance. Carbon nanotube (CNT), with its high stiffness and mechanical strength, is an attractive reinforcement for HA to surmount these issues. The last 7-8years have seen a number of studies to explore the efficiency of CNT reinforcement in strengthening HA, in the form of composites and coatings. Impressive improvement in the fracture toughness and wear resistance of HA with CNT reinforcement and beneficial effects on biocompatibility has sparked further research interests, for possible clinical applications. This review article aims to cover a wide span of this exciting and expanding research arena - from detailed technical discussions on HA-CNT system, their processing techniques and the influence of CNT dispersion in the HA matrix. Role of CNT in the improvement of mechanical properties and tribological behavior of the composite has been discussed in light of different processing techniques. Other important issues related to HA-CNT system, e.g., phase transformation and crystallinity of HA and HA-CNT interfacial bonding has been stressed upon. Biocompatibility of HA-CNT composites, which is extremely important for its intended orthopedic application, has been summarized with an overview of the present status. An in-depth analysis of the information presented in this review facilitates a better understanding of the current state of HA-CNT research and allows framing guidelines toward future research direction for its successful clinical application.
羟基磷灰石（HA）在骨科植入物中的应用存在断裂韧性低和耐磨性差的问题。碳纳米管（CNT）具有高刚度和机械强度，是一种有吸引力的增强材料，可用于增强HA以克服这些问题。在过去的7 - 8年里，已经有许多研究以复合材料和涂层的形式探索CNT增强HA的有效性。通过CNT增强，HA的断裂韧性和耐磨性得到了显著改善，并且对生物相容性产生了有益影响，这引发了进一步的研究兴趣，以探索其在临床中的可能应用。这篇综述文章旨在涵盖这个令人兴奋且不断扩展的研究领域的广泛内容——从关于HA - CNT系统的详细技术讨论、它们的加工技术以及CNT在HA基体中的分散影响。根据不同的加工技术，讨论了CNT在改善复合材料的力学性能和摩擦学行为方面的作用。还强调了与HA - CNT系统相关的其他重要问题，例如HA的相变和结晶度以及HA - CNT界面结合。HA - CNT复合材料的生物相容性对于其预期的骨科应用极为重要，本文对其现状进行了概述总结。对本综述中所呈现信息的深入分析有助于更好地理解HA - CNT的研究现状，并为其成功临床应用的未来研究方向制定指导方针。
