为淋病选择新疗法：我们需要考虑对泛基因组的影响。一种观点。
Choosing New Therapies for Gonorrhoea: We Need to Consider the Impact on the Pan- Genome. A Viewpoint.
作者信息
Kenyon Chris, Laumen Jolein, Manoharan-Basil Sheeba
机构信息
HIV/STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium.
Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7701, South Africa.
出版信息
Antibiotics (Basel). 2021 May 1;10(5):515. doi: 10.3390/antibiotics10050515.
The development of new gonorrhoea treatment guidelines typically considers the resistance-inducing effect of the treatment only on . Antimicrobial resistance in has, however, frequently first emerged in commensal species and then been passed on to via transformation. This creates the rationale for considering the effect of gonococcal therapies on resistance in commensal . We illustrate the benefits of this pan- strategy by evaluating three contemporary treatment options for -ceftriaxone plus azithromycin, monotherapy with ceftriaxone and zoliflodacin.
新的淋病治疗指南的制定通常仅考虑治疗对……的耐药诱导作用。然而，……中的抗菌药物耐药性常常首先在共生……物种中出现，然后通过转化传递给……。这为考虑淋球菌治疗对共生……耐药性的影响提供了理论依据。我们通过评估三种当代治疗方案——头孢曲松加阿奇霉素、头孢曲松单药治疗和佐利弗洛达辛，来说明这种泛……策略的益处。
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