Kanesaka Izumo, Foschi Claudio, Marangoni Antonella, Adamson Paul C, Klausner Jeffrey, Dong Huan Vinh, Vanbaelen Thibaut, De Baetselier Irith, de Block Tessa, Manoharan-Basil Sheeba Santhini, Kenyon Chris
Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium; Department of Infection Control and Prevention, Faculty of Nursing, Toho University, Japan.
Department of Medical and Surgical Sciences, Section of Microbiology, Alma Mater Studiorum - University of Bologna, Bologna, Italy; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Int J Infect Dis. 2025 May;154:107870. doi: 10.1016/j.ijid.2025.107870. Epub 2025 Mar 7.
This perspective explores the utility of commensal Neisseria species as an early warning sign of excessive antimicrobial consumption. Little is known as to how the prevalence and antimicrobial susceptibility of various commensal Neisseria species varies between populations around the world. We compared the prevalence and antimicrobial susceptibilities of oral commensal Neisseria species in the general population and cohorts of men who have sex with men (MSM) in four countries with available data - Belgium, Italy, Japan and Vietnam. In individuals where Neisseria spp. were detected, N. subflava was present in 70-100% of individuals in the different studies. The N. subflava azithromycin and ciprofloxacin minimum inhibitory concentrations (MICs) were higher in the MSM than in the general population. The MICs of all Neisseria spp. were very similar in the general populations of Belgium and Italy. For all Neisseria spp., azithromycin and ceftriaxone MICs were higher, whereas ciprofloxacin MICs were lower in Belgium and Italy than in Japan. The higher azithromycin and ciprofloxacin MICs observed in the cohorts of MSM compared to the general population and the higher ciprofloxacin MICs in Japan compared to Belgium and Italy are commensurate with the most commonly antimicrobial prescribed in these populations. Our results support using commensal Neisseria species as an early warning system of excessive antimicrobial consumption.
本观点探讨了共生奈瑟菌属作为抗菌药物过度使用早期预警信号的效用。关于世界各地不同人群中各种共生奈瑟菌属的流行情况和抗菌药物敏感性如何变化，目前所知甚少。我们比较了在有可用数据的四个国家（比利时、意大利、日本和越南）的普通人群以及男男性行为者（MSM）队列中口腔共生奈瑟菌属的流行情况和抗菌药物敏感性。在检测到奈瑟菌属的个体中，不同研究显示70%-100%的个体存在微黄奈瑟菌。微黄奈瑟菌对阿奇霉素和环丙沙星的最低抑菌浓度（MIC）在MSM中高于普通人群。比利时和意大利普通人群中所有奈瑟菌属的MIC非常相似。对于所有奈瑟菌属，比利时和意大利的阿奇霉素和头孢曲松MIC较高，而环丙沙星MIC低于日本。与普通人群相比，在MSM队列中观察到的阿奇霉素和环丙沙星MIC较高，以及与比利时和意大利相比，日本的环丙沙星MIC较高，这与这些人群中最常用的抗菌药物相符。我们的结果支持将共生奈瑟菌属用作抗菌药物过度使用的早期预警系统。
