Vaverková Kristýna, Kracík Martin, Ryšková Lenka, Paterová Pavla, Kukla Rudolf, Hobzová Lenka, Špánek Roman, Žemličková Helena
Department of Clinical Microbiology, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, 50005 Hradec Kralove, Czech Republic.
Department of Clinical Microbiology and Imunology, Regional Hospital Liberec, 46001 Liberec, Czech Republic.
Antibiotics (Basel). 2021 May 2;10(5):519. doi: 10.3390/antibiotics10050519.
is the most common pathogen responsible for hospital-acquired diarrhea. This complication of antibiotic treatment mainly endangers the health of elder patients. Preventing the development of infections (CDI) is still a challenge that needs to be addressed. In our study, the results of 872 positive stool samples were used to describe the epidemiological situation affected by a change in the prescription of fluoroquinolone antibiotics. In a total, 93 of strains were typed by polymerase chain reaction (PCR) and capillary gel electrophoresis. Between years 2014 and 2018 the decline in the fluoroquinolones consumption was 69.3 defined daily dose (DDD) per 1000 patient-days (from 103.3 to 34.0), in same period CDI incidence declined by 1.3 cases per 10,000 patient-bed days (from 5.6 to 4.3). Results of epidemiologic and statistical analysis shows that decline in fluoroquinolones consumption has significant influence on CDI incidence and prevalence of hypervirulent strains. In the University Hospital Hradec Králové properly managed antibiotic stewardship policy has reduced CDI incidence by 23.2% and lowered rate of hypervirulent ribotypes 001 and 176.
是医院获得性腹泻最常见的病原体。抗生素治疗的这种并发症主要危及老年患者的健康。预防艰难梭菌感染（CDI）的发生仍然是一个需要应对的挑战。在我们的研究中，872份粪便阳性样本的结果被用于描述受氟喹诺酮类抗生素处方变化影响的流行病学情况。总共93株菌株通过聚合酶链反应（PCR）和毛细管凝胶电泳进行分型。在2014年至2018年期间，氟喹诺酮类药物的消耗量下降了每1000患者日69.3限定日剂量（DDD）（从103.3降至34.0），同期CDI发病率下降了每10000患者床日1.3例（从5.6降至4.3）。流行病学和统计分析结果表明，氟喹诺酮类药物消耗量的下降对CDI发病率和高毒力菌株的流行率有显著影响。在赫拉德茨克拉洛韦大学医院，合理管理的抗生素管理政策使CDI发病率降低了23.2%，并降低了高毒力核糖体分型001和176的发生率。
