Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute of Drug Discovery, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Cells. 2021 May 4;10(5):1100. doi: 10.3390/cells10051100.
Evading host immune surveillance is one of the hallmarks of cancer. Immune checkpoint therapy, which aims to eliminate cancer progression by reprogramming the antitumor immune response, currently occupies a solid position in the rapidly expanding arsenal of cancer therapy. As most immune checkpoints are membrane glycoproteins, mounting attention is drawn to asking how protein glycosylation affects immune function. The answers to this fundamental question will stimulate the rational development of future cancer diagnostics and therapeutic strategies.
逃避宿主免疫监视是癌症的标志之一。免疫检查点疗法旨在通过重新编程抗肿瘤免疫反应来消除癌症进展，目前在迅速扩展的癌症治疗武器库中占据着坚实的地位。由于大多数免疫检查点都是膜糖蛋白，因此人们越来越关注蛋白糖基化如何影响免疫功能。这个基本问题的答案将激发对未来癌症诊断和治疗策略的合理发展。
