Hinterleitner Martina, Sipos Bence, Wagner Verena, Grottenthaler Julia M, Lauer Ulrich M, Zender Lars, Hinterleitner Clemens
Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076 Tuebingen, Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076 Tuebingen, Germany.
Cancers (Basel). 2021 May 11;13(10):2286. doi: 10.3390/cancers13102286.
Neuroendocrine neoplasms (NENs) encompass a heterogeneous group of tumors. Whereas low-grade neuroendocrine tumors (NETs) are histologically well-differentiated, highly aggressive neuroendocrine carcinomas (NECs) are characterized by a high proliferation rate and a worse clinical outcome. Since most NEN patients need monitoring of tumor progress and response to treatment for a long period of time, especially in metastatic disease, reliable, dynamic, and easy-to-assess biomarkers are needed. In this prospective study, we identified platelet-expressed synaptophysin (pSyn) as a novel biomarker in NENs. The level of pSyn in NENs was significantly upregulated compared to healthy donors. pSyn was positively correlated with higher tumor stages, the occurrence of metastasis, histological grading, and higher tumor proliferation (Ki67). Most importantly, high pSyn expression in our NEN cohort was shown to predict shorter progression-free survival (PFS). In conclusion, our data highlight the potential of pSyn as a novel biomarker in NENs reflecting tumor stages, grading, and prognosis.
神经内分泌肿瘤（NENs）是一组异质性肿瘤。低级别神经内分泌肿瘤（NETs）在组织学上分化良好，而高侵袭性神经内分泌癌（NECs）的特征是增殖率高且临床预后较差。由于大多数NEN患者需要长期监测肿瘤进展和对治疗的反应，尤其是在转移性疾病中，因此需要可靠、动态且易于评估的生物标志物。在这项前瞻性研究中，我们确定血小板表达的突触素（pSyn）是NENs中的一种新型生物标志物。与健康供体相比，NENs中pSyn的水平显著上调。pSyn与更高的肿瘤分期、转移的发生、组织学分级以及更高的肿瘤增殖（Ki67）呈正相关。最重要的是，在我们的NEN队列中，高pSyn表达被证明可预测无进展生存期（PFS）更短。总之，我们的数据突出了pSyn作为NENs中反映肿瘤分期、分级和预后的新型生物标志物的潜力。
