Wang Kang, Zhou Qin, Jiang Zhongbiao, Liu Shiping, Tang Hanfen
Department of Cardiology, Second Xiangya Hospital of Central South University, Changsha, China.
Department of General Surgery, Clinical Research Center for Breast Disease, Second Xiangya Hospital of Central South University, Changsha, China.
Front Endocrinol (Lausanne). 2024 Sep 17;15:1442586. doi: 10.3389/fendo.2024.1442586. eCollection 2024.
It remains unknown whether composite-dietary-antioxidant-index (CDAI) is associated with the risk of sarcopenia. This study investigated the association of CDAI with sarcopenia risk among general US adults.
A total of 10,093 participants were enrolled in the National Health and Nutrition Examination Surveys (NHANES) from 6 survey cycles (2003-2004, 2005-2006, 2011-2012, 2013-2014, 2015-2016 and 2017-2018). Multivariate logistic regression was carried out to examine the relationship between CDAI and the risk of sarcopenia. Restricted cubic spline (RCS) curves were employed to analyze nonlinear relationships.
In a multi-variable logistic regression model adjusting for demographics, lifestyle, economic status and other dietary factors, higher CDAI score was related to a lower risk of sarcopenia among US adults. Compared the highest quartile of CDAI score with the lowest, the OR and 95%CI were 0.49 (0.31-0.75). Furthermore, the RCS demonstrated a linear dose-response relationship between CDAI and sarcopenia ( =0.92). These results remained consistent across subgroups stratified by age, sex, physical activity, drinking status, body mass index (BMI), smoking habits, energy intake, and Healthy Eating Index (HEI) score. In addition, the favorable associations of CDAI were primarily attributed to Vitamin E intake.
A higher CDAI score was associated with a lower risk of sarcopenia. According to these results, a greater adherence to CDAI may benefit sarcopenia prevention in adults.
复合膳食抗氧化指数（CDAI）是否与肌肉减少症风险相关尚不清楚。本研究调查了美国普通成年人中CDAI与肌肉减少症风险之间的关联。
从6个调查周期（2003 - 2004年、2005 - 2006年、2011 - 2012年、2013 - 2014年、2015 - 2016年和2017 - 2018年）的国家健康和营养检查调查（NHANES）中纳入了总共10,093名参与者。进行多变量逻辑回归以检查CDAI与肌肉减少症风险之间的关系。采用限制立方样条（RCS）曲线分析非线性关系。
在调整了人口统计学、生活方式、经济状况和其他饮食因素的多变量逻辑回归模型中，较高的CDAI评分与美国成年人较低的肌肉减少症风险相关。将CDAI评分的最高四分位数与最低四分位数进行比较，优势比（OR）和95%置信区间（CI）为0.49（0.31 - 0.75）。此外，RCS显示CDAI与肌肉减少症之间存在线性剂量反应关系（ =0.92）。这些结果在按年龄、性别、身体活动、饮酒状况、体重指数（BMI）、吸烟习惯、能量摄入和健康饮食指数（HEI）评分分层的亚组中保持一致。此外，CDAI的有益关联主要归因于维生素E的摄入。
较高的CDAI评分与较低的肌肉减少症风险相关。根据这些结果，更多地遵循CDAI可能有益于成年人肌肉减少症的预防。
