Demosthenous Christos, Sakellari Ioanna, Douka Vassiliki, Papayanni Penelope Georgia, Anagnostopoulos Achilles, Gavriilaki Eleni
Hematology Department-BMT Unit, G Papanicolaou Hospital, 57010 Thessaloniki, Greece.
J Clin Med. 2021 May 11;10(10):2050. doi: 10.3390/jcm10102050.
Myeloid-derived suppressor cells (MDSCs) are implicated in the complex interplay involving graft-versus-leukemia (GVL) effects and graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HCT) in hematologic malignancies.
A review of literature through PubMed was undertaken to summarize the published evidence on the pathophysiology and clinical implications of MDSCs in allo-HCT. Literature sources published in English since 1978 were searched, using the terms Natural Suppressor (NS) cells, MDSCs, GVHD, and allo-HCT.
In vivo studies demonstrated that MDSCs derived from mobilization protocols could strongly suppress allo-responses mediated by T cells and enhance T-Reg activity, thus inhibiting GVHD toxicity. However, the influence of MDSCs on the GVL effect is not fully defined.
The induction or maintenance of MDSC suppressive function would be advantageous in suppressing inflammation associated with GVHD. Pathways involved in MDSC metabolism and the inflammasome signaling are a promising field of study to elucidate the function of MDSCs in the pathogenesis of GVHD and translate these findings to a clinical setting.
髓系来源的抑制性细胞（MDSCs）参与了血液系统恶性肿瘤异基因造血干细胞移植（allo-HCT）后移植物抗白血病（GVL）效应和移植物抗宿主病（GVHD）的复杂相互作用。
通过PubMed对文献进行综述，以总结已发表的关于MDSCs在allo-HCT中的病理生理学和临床意义的证据。检索了自1978年以来以英文发表的文献来源，使用的检索词为自然抑制（NS）细胞、MDSCs、GVHD和allo-HCT。
体内研究表明，动员方案产生的MDSCs可强烈抑制T细胞介导的同种异体反应并增强调节性T细胞（T-Reg）活性，从而抑制GVHD毒性。然而，MDSCs对GVL效应的影响尚未完全明确。
诱导或维持MDSC的抑制功能在抑制与GVHD相关的炎症方面将具有优势。参与MDSC代谢和炎性小体信号传导的途径是一个有前景的研究领域，有助于阐明MDSCs在GVHD发病机制中的功能，并将这些发现转化到临床应用中。
