Dietrich Meghan P, Pravin Raam, Furst Jacob, Jason Leonard A
Center for Community Research, DePaul University, 990 W Fullerton Ave, Ste 3100, Chicago, IL 60614, USA.
Healthcare (Basel). 2025 May 26;13(11):1255. doi: 10.3390/healthcare13111255.
BACKGROUND/OBJECTIVES: Impaired sleep is one of the core symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), yet the mechanisms and impact of sleep-related issues are poorly understood. Sleep dysfunctions for patients with ME/CFS include frequent napping, difficulties falling asleep, waking up early, and sleep reversal patterns (e.g., sleeping throughout the day and staying awake throughout the night). The current study focuses on sleep reversal for patients with ME/CFS.
We explored the symptoms and functional impairment of those with and without sleep reversal by analyzing the responses of a large international sample (N = 2313) using the DePaul Symptom Questionnaire (DSQ) and Medical Outcomes Study 36-item Short-Form Health Survey (SF-36).
We found that those in our Sleep Reversal group (N = 327) compared to those without sleep reversal (N = 1986) reported higher symptom burden for 53 out of 54 DSQ symptoms and greater impairments for all six SF-36 subscales. The most accurate predictors of sleep reversal included age ( < 0.05), body mass index ( < 0.05), eleven DSQ symptoms ( < 0.01), and two SF-36 subscales ( < 0.01).
These features provide clues regarding some of the possible pathophysiological underpinnings of sleep reversal among those with ME/CFS.
背景/目的：睡眠障碍是肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的核心症状之一，但与睡眠相关问题的机制和影响仍知之甚少。ME/CFS患者的睡眠功能障碍包括频繁小憩、入睡困难、早醒以及睡眠颠倒模式（例如，白天睡觉，晚上清醒）。本研究聚焦于ME/CFS患者的睡眠颠倒问题。
我们通过分析一个大型国际样本（N = 2313）使用德保罗症状问卷（DSQ）和医学结果研究36项简短健康调查（SF - 36）的回答，探讨了有和没有睡眠颠倒的患者的症状和功能损害。
我们发现，与没有睡眠颠倒的患者（N = 1986）相比，我们的睡眠颠倒组（N = 327）在54项DSQ症状中有53项报告了更高的症状负担，并且在所有六个SF - 36子量表上有更大的损害。睡眠颠倒最准确的预测因素包括年龄（<0.05）、体重指数（<0.05）、11项DSQ症状（<0.01）和两项SF - 36子量表（<0.01）。
这些特征为ME/CFS患者睡眠颠倒的一些可能病理生理基础提供了线索。
