Fanlo-Maresma Marta, Candás-Estébanez Beatriz, Esteve-Luque Virginia, Padró-Miquel Ariadna, Escrihuela-Vidal Francesc, Carratini-Moraes Monica, Corbella Emili, Corbella Xavier, Pintó Xavier
Cardiovascular Risk Unit-Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
J Clin Med. 2021 May 20;10(10):2218. doi: 10.3390/jcm10102218.
SLE is associated with increased cardiovascular risk. The objective of this study was to determine the prevalence of asymptomatic carotid atherosclerosis to analyze its relationship with dyslipidemia and related genetic factors in a population of patients with SLE. Seventy-one SLE female patients were recruited. Carotid ultrasound, laboratory profiles, and genetic analysis of the , and genes were performed. SLE patients were divided into two groups according to the presence or absence of carotid plaques. Patients with carotid plaque had higher plasma TG (1.5 vs. 0.9 mmol/L, = 0.001), Non-HDL-C (3.5 vs. 3.1 mmol/L, = 0.025), and apoB concentrations (1.0 vs. 0.9 g/L, = 0.010) and a higher prevalence of hypertension (80 vs. 37.5%, = 0.003) than patients without carotid plaque. The C-allele was present in 83.3% and 16.7% ( = 0.047) of patients with and without carotid plaque, respectively. The CC genotype (OR = 0.026; 95% CI: 0.001 to 0.473, = 0.014), an increase of 1 mmol/L in TG concentrations ( = 12.550; 95% CI: 1.703 to 92.475, = 0.013) and to be hypertensive ( = 9.691; 95% CI: 1.703 to 84.874, = 0.040) were independently associated with carotid atherosclerosis. In summary, plasma TG concentrations, CC homozygosity, and hypertension are independent predictors of carotid atherosclerosis in women with SLE.
系统性红斑狼疮（SLE）与心血管疾病风险增加相关。本研究的目的是确定无症状性颈动脉粥样硬化的患病率，分析其与SLE患者血脂异常及相关遗传因素的关系。招募了71名SLE女性患者。进行了颈动脉超声检查、实验室检查以及对[具体基因名称1]、[具体基因名称2]和[具体基因名称3]基因的遗传分析。根据是否存在颈动脉斑块将SLE患者分为两组。有颈动脉斑块的患者血浆甘油三酯（TG）水平较高（1.5 vs. 0.9 mmol/L，P = 0.001）、非高密度脂蛋白胆固醇（Non-HDL-C）水平较高（3.5 vs. 3.1 mmol/L，P = 0.025）、载脂蛋白B（apoB）浓度较高（1.0 vs. 0.9 g/L，P = 0.010），且高血压患病率高于无颈动脉斑块的患者（80% vs. 37.5%，P = 0.003）。[具体基因名称4]的C等位基因在有和无颈动脉斑块的患者中出现的比例分别为83.3%和16.7%（P = 0.047）。[具体基因名称4]的CC基因型（比值比[OR]=0.026；95%置信区间[CI]：0.001至0.473，P = 0.014）、TG浓度每增加1 mmol/L（P = 12.550；95% CI：1.703至92.475，P = 0.013）以及患有高血压（P = 9.691；95% CI：1.703至84.874, P = 0.040）均与颈动脉粥样硬化独立相关。总之，血浆TG浓度、[具体基因名称4]的CC纯合性以及高血压是SLE女性患者颈动脉粥样硬化的独立预测因素。
