Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Department of Medicine, Västerviks Sjukhus Hospital, 593 33 Västerviks, Sweden.
Biomolecules. 2023 Feb 21;13(3):401. doi: 10.3390/biom13030401.
Impaired lipid metabolism contributes to accelerated inflammatory responses in addition to promoting the formation of atherosclerosis in systemic lupus erythematosus (SLE). We aimed to evaluate the lipid profile, inflammatory markers, and vascular diagnostic tests in active SLE patients to clarify the association between dyslipidemia and early vascular damage.
51 clinically active SLE patients and 41 age- and gender-matched control subjects were enrolled in the study. Lipoprotein subfractions were detected by Lipoprint. Brachial artery flow-mediated dilation and common carotid intima-media thickness were detected by ultrasonography. Arterial stiffness indicated by augmentation index (Aix) and pulse wave velocity was measured by arteriography.
We found significantly higher Aix, higher VLDL ratio, plasma triglyceride, ApoB100, and small HDL, as well as lower HDL-C, large HDL, and ApoA1 in patients with SLE. There was a significant positive correlation of Aix with triglyceride, VLDL, IDL-C, IDL-B, and LDL1. A backward stepwise multiple regression analysis showed IDL-C subfraction to be the best predictor of Aix.
Our results indicate that in young patients with SLE, triglyceride-rich lipoproteins influence vascular function detected by Aix. These parameters may be assessed and integrated into the management plan for screening cardiovascular risk in patients with SLE.
脂代谢异常除了促进系统性红斑狼疮（SLE）中动脉粥样硬化的形成外，还会导致炎症反应加速。我们旨在评估活动期 SLE 患者的血脂谱、炎症标志物和血管诊断检查，以阐明血脂异常与早期血管损伤之间的关系。
本研究纳入了 51 例临床活动期 SLE 患者和 41 例年龄和性别匹配的对照组。脂蛋白亚组分通过 Lipoprint 进行检测。肱动脉血流介导的扩张和颈总动脉内膜中层厚度通过超声进行检测。通过血管造影测量动脉僵硬度的增强指数（Aix）和脉搏波速度。
我们发现 SLE 患者的 Aix、VLDL 比值、血浆甘油三酯、ApoB100 和小 HDL 显著升高，而 HDL-C、大 HDL 和 ApoA1 显著降低。Aix 与甘油三酯、VLDL、IDL-C、IDL-B 和 LDL1 呈显著正相关。向后逐步多元回归分析显示 IDL-C 亚组分是 Aix 的最佳预测因子。
我们的研究结果表明，在年轻的 SLE 患者中，富含甘油三酯的脂蛋白会影响 Aix 检测到的血管功能。这些参数可以进行评估，并整合到 SLE 患者的心血管风险筛查管理计划中。
