非酒精性脂肪性肝病患者中，肝纤维化程度与棕榈酸和胰岛素水平独立相关。
Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease.
机构信息
Institute of Nutrition Josué de Castro of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, Brazil.
Nutrition Course, Federal University of Rio de Janeiro (Campus UFRJ-Macaé), Macaé, Rio de Janeiro 27.930-560, Brazil.
出版信息
Nutrients. 2018 Oct 29;10(11):1586. doi: 10.3390/nu10111586.
Abstract
Changes in lipid metabolism occur during the development and progression non-alcoholic fatty liver disease (NAFLD). However, the fatty acid (FA) profile in red blood cells (RBC) from patients with liver fibrosis remains unexplored. Thus, the goal of this study was to evaluate the fatty acid profile in RBC, dietary lipid intake and insulin resistance indicators in patients with NAFLD, according to the degree of hepatic fibrosis. Using elastography, patients were classified with ( = 52) and without ( = 37) advanced liver fibrosis. The fatty acid profile in RBC was analyzed using gas chromatography and the lipid intake was evaluated through a 24-h dietary recall. Subjects with advanced liver fibrosis had higher levels of palmitic, stearic and oleic acid and total monounsaturated fatty acid (MUFA) and insulin ( < 0.05), and lower levels of elongase very long chain fatty acids protein-6 and the delta-5-desaturase enzymatic activity ( < 0.05). These results suggest a lack of regulation of enzymes related to FA metabolism in patients with advanced fibrosis.
摘要
脂质代谢在非酒精性脂肪性肝病（NAFLD）的发生和发展过程中发生变化。然而，纤维化患者的红细胞（RBC）中的脂肪酸（FA）谱仍未被探索。因此，本研究的目的是根据肝纤维化程度评估 NAFLD 患者 RBC 中的脂肪酸谱、膳食脂质摄入和胰岛素抵抗指标。使用超声弹性成像技术，将患者分为有（=52）和无（=37）进展性肝纤维化。使用气相色谱法分析 RBC 中的脂肪酸谱，并通过 24 小时膳食回顾评估脂质摄入。患有进展性肝纤维化的患者棕榈酸、硬脂酸和油酸以及总单不饱和脂肪酸（MUFA）和胰岛素水平更高（<0.05），而延伸酶非常长链脂肪酸蛋白-6 和 delta-5-去饱和酶酶活性水平更低（<0.05）。这些结果表明，在纤维化患者中，与 FA 代谢相关的酶缺乏调节。
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