Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Biomolecules. 2021 May 6;11(5):695. doi: 10.3390/biom11050695.
Hypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of acute pancreatitis (AP). However, pathogenetic association between gut microbiota and HTGAP remains unknown. In this study, we enrolled 30 HTGAP patients and 30 patients with AP that is evoked by other causes. The V3-V4 regions of 16S rRNA sequences of the gut microbiota were analyzed. Clinical characteristics, microbial diversity, taxonomic profile, microbiome composition, microbiological phenotype, and functional pathways were compared between the two groups. Our results showed that the HTGAP group had a higher proportion of severe AP (46.7% vs. 20.0%), organ failure (56.7% vs. 30.0%), and a longer hospital stay (18.0 days vs. 6.5 days). HTGAP group also had poorer microbial diversity, higher abundances of and , but lower abundances of , , and as compared with non-HTGAP group. Correlation analysis revealed that gut bacterial taxonomic and functional changes were linked with local and systemic complications, ICU admission, and mortality. This study revealed that alterations of gut microbiota were associated with disease severity and poor prognosis in HTGAP patients, indicating a potential pathophysiological link between gut microbiota and hypertriglyceridemia related acute pancreatitis.
高脂血症相关性急性胰腺炎（HTGAP）与疾病严重程度和发病率增加有关。肠道菌群在急性胰腺炎（AP）的进展中起着重要作用。然而，肠道微生物群与 HTGAP 之间的发病关联尚不清楚。在这项研究中，我们纳入了 30 例 HTGAP 患者和 30 例由其他原因引起的 AP 患者。分析了肠道微生物群 16S rRNA 序列的 V3-V4 区。比较了两组间的临床特征、微生物多样性、分类群谱、微生物组组成、微生物表型和功能途径。我们的结果表明，HTGAP 组中重症 AP 的比例较高（46.7%比 20.0%）、器官衰竭的比例较高（56.7%比 30.0%）、住院时间较长（18.0 天比 6.5 天）。与非-HTGAP 组相比，HTGAP 组的微生物多样性较差， 和 的丰度较高，而 、 、 和 的丰度较低。相关性分析表明，肠道细菌分类和功能的变化与局部和全身并发症、入住 ICU 和死亡率有关。本研究表明，肠道微生物群的改变与 HTGAP 患者的疾病严重程度和预后不良有关，提示肠道微生物群与高脂血症相关的急性胰腺炎之间存在潜在的病理生理联系。
