Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
mSystems. 2024 Oct 22;9(10):e0066524. doi: 10.1128/msystems.00665-24. Epub 2024 Aug 30.
Gut microbiome plays a vital role in the intestinal ecosystem and has close association with metabolites. Due to the development of metabolomics and microbiomics, recent studies have observed that alteration of either the gut microbiome or metabolites may have effects on the progression of pancreatitis. Several new treatments based on the gut microbiome or metabolites have been studied extensively in recent years. Gut microbes, such as , , and , and metabolites, such as short-chain fatty acids, bile acids, vitamin, hydrogen sulfide, and alcohol, have different effects on pancreatitis. Some preliminary studies about new intervention measures were based on the gut microbiome and metabolites such as diet, prebiotic, herbal medicine, and fecal microbiota transplantation. This review aims to summarize the recent advances about the gut microbiome, metabolites, and pancreatitis in order to determine the potential beneficial role of the gut microbiome and metabolites in pancreatitis.
肠道微生物群在肠道生态系统中起着至关重要的作用，并且与代谢物密切相关。由于代谢组学和微生物组学的发展，最近的研究观察到肠道微生物群或代谢物的改变可能对胰腺炎的进展产生影响。近年来，基于肠道微生物群或代谢物的几种新治疗方法已经得到了广泛的研究。肠道微生物，如、、和，以及代谢物，如短链脂肪酸、胆汁酸、维生素、硫化氢和酒精，对胰腺炎有不同的影响。一些关于新干预措施的初步研究是基于肠道微生物群和代谢物，如饮食、益生菌、草药和粪便微生物群移植。本综述旨在总结肠道微生物群、代谢物和胰腺炎的最新进展，以确定肠道微生物群和代谢物在胰腺炎中的潜在有益作用。
