肠道微生物群在心血管疾病发病机制中的神经免疫作用
The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease.
作者信息
Suslov Andrey V, Chairkina Elizaveta, Shepetovskaya Maria D, Suslova Irina S, Khotina Victoria A, Kirichenko Tatiana V, Postnov Anton Y
机构信息
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, 8-2 Trubetskaya Str., 119992 Moscow, Russia.
Central State Medical Academy of the Administrative Department of the President of the Russian Federation, 19-1A Marshal Timoshenko Str., 121359 Moscow, Russia.
出版信息
J Clin Med. 2021 May 6;10(9):1995. doi: 10.3390/jcm10091995.
Currently, a bidirectional relationship between the gut microbiota and the nervous system, which is considered as microbiota-gut-brain axis, is being actively studied. This axis is believed to be a key mechanism in the formation of somatovisceral functions in the human body. The gut microbiota determines the level of activation of the hypothalamic-pituitary system. In particular, the intestinal microbiota is an important source of neuroimmune mediators in the pathogenesis of cardiovascular disease. This review reflects the current state of publications in PubMed and Scopus databases until December 2020 on the mechanisms of formation and participation of neuroimmune mediators associated with gut microbiota in the development of cardiovascular disease.
目前，肠道微生物群与神经系统之间的双向关系，即被认为是微生物群-肠道-脑轴，正在被积极研究。该轴被认为是人体躯体内脏功能形成的关键机制。肠道微生物群决定下丘脑-垂体系统的激活水平。特别是，肠道微生物群是心血管疾病发病机制中神经免疫介质的重要来源。本综述反映了截至2020年12月PubMed和Scopus数据库中关于与肠道微生物群相关的神经免疫介质在心血管疾病发生发展中的形成机制和参与情况的出版物的现状。
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