Haegeman Andy, De Leeuw Ilse, Mostin Laurent, Campe Willem Van, Aerts Laetitia, Venter Estelle, Tuppurainen Eeva, Saegerman Claude, De Clercq Kris
Infectious Diseases in Animals, Exotic and Particular Diseases, Sciensano, Groeselenberg 99, B-1180 Brussels, Belgium.
Experimental Center Machelen, Sciensano, Kerklaan 68, B-1830 Machelen, Belgium.
Vaccines (Basel). 2021 May 8;9(5):473. doi: 10.3390/vaccines9050473.
Vaccines form the cornerstone of any control, eradication and preventative strategy and this is no different for lumpy skin disease. However, the usefulness of a vaccine is determined by a multiplicity of factors which include stability, efficiency, safety and ease of use, to name a few. Although the vaccination campaign in the Balkans against lumpy skin disease virus (LSDV) was successful and has been implemented with success in the past in other countries, data of vaccine failure have also been reported. It was therefore the purpose of this study to compare five homologous live attenuated LSDV vaccines (LSDV LAV) in a standardized setting. All five LSDV LAVs studied were able to protect against a challenge with virulent LSDV. Aside from small differences in serological responses, important differences were seen in side effects such as a local reaction and a Neethling response upon vaccination between the analyzed vaccines. These observations can have important implications in the applicability in the field for some of these LSDV LAVs.
疫苗是任何控制、根除和预防策略的基石，对于结节性皮肤病来说也不例外。然而，疫苗的有效性取决于多种因素，包括稳定性、效率、安全性和易用性等。尽管巴尔干地区针对结节性皮肤病病毒（LSDV）的疫苗接种运动取得了成功，并且过去在其他国家也成功实施过，但也有疫苗接种失败的数据报道。因此，本研究的目的是在标准化环境中比较五种同源减毒活LSDV疫苗（LSDV LAV）。所研究的所有五种LSDV LAV都能够抵御强毒LSDV的攻击。除了血清学反应存在微小差异外，在所分析的疫苗之间，在诸如局部反应和接种疫苗后的内斯林反应等副作用方面也存在重要差异。这些观察结果可能对其中一些LSDV LAV在该领域的适用性产生重要影响。
