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从山西老陈醋中提取的多酚通过抑制MAPK/NF-κB信号通路激活来抑制脂多糖诱导的RAW264.7巨噬细胞和ICR小鼠的炎症反应。

Polyphenols Extracted from Shanxi-Aged Vinegar Inhibit Inflammation in LPS-Induced RAW264.7 Macrophages and ICR Mice via the Suppression of MAPK/NF-κB Pathway Activation.

作者信息

Du Peng, Song Jia, Qiu Huirui, Liu Haorui, Zhang Li, Zhou Junhan, Jiang Shengping, Liu Jinyu, Zheng Yu, Wang Min

机构信息

Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science and Technology), Ministry of Education, Tianjin 300457, China.

State Key Laboratory of Food Nutrition and Safety, Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.

出版信息

Molecules. 2021 May 7;26(9):2745. doi: 10.3390/molecules26092745.

DOI:10.3390/molecules26092745
PMID:34067016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8124351/
Abstract

Shanxi-aged vinegar, a traditional Chinese grain-fermented food that is rich in polyphenols, has been shown to have therapeutic effects on a variety of diseases. However, there has been no comprehensive evaluation of the anti-inflammatory activity of polyphenols extracted from Shanxi-aged vinegar (SAVEP) to date. The anti-inflammatory activities of SAVEP, both in RAW 264.7 macrophages and mice, were extensively investigated for the potential application of SAVEP as a novel anti-inflammatory agent. In order to confirm the notion that polyphenols could improve inflammatory symptoms, SAVEP was firstly detected by gas chromatography mass spectrometry (GC-MS). In total, 19 polyphenols were detected, including 12 phenolic acids. The study further investigated the protective effect of SAVEP on lipopolysaccharide-induced inflammation in RAW264.7 macrophages and ICR mice. The results showed that compared with those of the model group, SAVEP could remarkably recover the inflammation of macrophage RAW264.7 and ICR mice. SAVEP can normalise the expression of related proteins via the suppression of MAPK/NF-κB pathway activation, inhibiting the expression of iNOS and COX-2 proteins, and consequently the production of inflammatory factors, thus alleviating inflammatory stress. These results suggest that SAVEP may have a potential function against inflammation.

摘要

山西陈醋是一种富含多酚的中国传统谷物发酵食品，已被证明对多种疾病具有治疗作用。然而，迄今为止，尚未对从山西陈醋中提取的多酚（SAVEP）的抗炎活性进行全面评估。为了探究SAVEP作为一种新型抗炎剂的潜在应用，我们广泛研究了SAVEP在RAW 264.7巨噬细胞和小鼠中的抗炎活性。为了证实多酚可以改善炎症症状的观点，首先通过气相色谱 - 质谱联用（GC-MS）对SAVEP进行了检测。总共检测到19种多酚，其中包括12种酚酸。该研究进一步考察了SAVEP对脂多糖诱导的RAW264.7巨噬细胞和ICR小鼠炎症的保护作用。结果表明，与模型组相比，SAVEP能够显著缓解巨噬细胞RAW264.7和ICR小鼠的炎症。SAVEP可以通过抑制MAPK/NF-κB信号通路的激活来使相关蛋白的表达恢复正常，抑制iNOS和COX-2蛋白的表达，从而减少炎症因子的产生，进而减轻炎症应激。这些结果表明，SAVEP可能具有潜在的抗炎功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/0a980217fd09/molecules-26-02745-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/52f1defeb2fa/molecules-26-02745-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/71de50ed47f1/molecules-26-02745-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/c97e5114549a/molecules-26-02745-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/c757cd5c44ed/molecules-26-02745-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/c16d8c5152ff/molecules-26-02745-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/9ba1f40701c6/molecules-26-02745-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/fe8cca73b51d/molecules-26-02745-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/0a980217fd09/molecules-26-02745-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/52f1defeb2fa/molecules-26-02745-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/71de50ed47f1/molecules-26-02745-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/c97e5114549a/molecules-26-02745-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/c757cd5c44ed/molecules-26-02745-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/c16d8c5152ff/molecules-26-02745-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/9ba1f40701c6/molecules-26-02745-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/fe8cca73b51d/molecules-26-02745-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6723/8124351/0a980217fd09/molecules-26-02745-g008.jpg

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