糖尿病肾病患者肾脏中线粒体过度增大
Excessively Enlarged Mitochondria in the Kidneys of Diabetic Nephropathy.
作者信息
Kim Kiyoung, Lee Eun-Young
机构信息
Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Korea.
Department of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.
出版信息
Antioxidants (Basel). 2021 May 7;10(5):741. doi: 10.3390/antiox10050741.
Abstract
Diabetic nephropathy (DN) is the most serious complication of diabetes and a leading cause of kidney failure and mortality in patients with diabetes. However, the exact pathogenic mechanisms involved are poorly understood. Impaired mitochondrial function and accumulation of damaged mitochondria due to increased imbalance in mitochondrial dynamics are known to be involved in the development and progression of DN. Accumulating evidence suggests that aberrant mitochondrial fission is involved in the progression of DN. Conversely, studies linking excessively enlarged mitochondria to DN pathogenesis are emerging. In this review, we summarize the current concepts of imbalanced mitochondrial dynamics and their molecular aspects in various experimental models of DN. We discuss the recent evidence of enlarged mitochondria in the kidneys of DN and examine the possibility of a therapeutic application targeting mitochondrial dynamics in DN.
摘要
糖尿病肾病（DN）是糖尿病最严重的并发症，也是糖尿病患者肾衰竭和死亡的主要原因。然而，其确切的致病机制尚不清楚。已知线粒体功能受损以及由于线粒体动力学失衡加剧导致受损线粒体的积累与DN的发生和发展有关。越来越多的证据表明，异常的线粒体分裂参与了DN的进展。相反，将过度增大的线粒体与DN发病机制联系起来的研究也不断涌现。在本综述中，我们总结了在各种DN实验模型中线粒体动力学失衡及其分子层面的当前概念。我们讨论了DN患者肾脏中线粒体增大的最新证据，并探讨了针对DN中线粒体动力学进行治疗应用的可能性。
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