Yunnan Institute of Food Safety, Kunming University of Science and Technology, No. 727 South Jingming Road, Kunming, Yunnan, 650500, China.
Yunnan Institute of Food Safety, Kunming University of Science and Technology, No. 727 South Jingming Road, Kunming, Yunnan, 650500, China.
Food Chem Toxicol. 2019 Jul;129:30-37. doi: 10.1016/j.fct.2019.04.020. Epub 2019 Apr 19.
Rambutan peel phenolics (RPP) have high antioxidant and anti-inflammatory activities. Leu-Ser-Gly-Tyr-Gly-Pro (LSGYGP) possesses good radical scavenging activity and matrix metalloproteinase (MMPs) inhibitory ability. These underlying mechanisms indicated that RPP and LSGYGP may be used for antiphotoaging. Few data on the effects of RPP and LSGYGP on in vivo photoaging are available. We evaluated the effects of RPP and/or LSGYGP on ultraviolet (UV)-induced hairless mice skin photoaging. In particular, we analyzed the additive effect of RPP and LSGYGP. The biochemical indices of mice skin, including composition (collagen and hyaluronic acid [HA] contents), oxidant stress (antioxidant enzyme activities and glutathione and malondialdehyde contents), MMPs (MMP-1, MMP-3, and MMP-9 levels), inflammatory cytokines (interleukin (IL)-1α, tumor nuclear factor-α, and IL-6 levels) and the phosphorylation of the mitogen-activated protein kinase pathway, were determined. Results showed a protective effect of RPP and/or LSGYGP on photoaging skin. LSGYGP showed considerable effects on skin collagen and HA contents. RPP showed improved effects on the regulation of the oxidant stress and inflammatory cytokine levels. RPP and LSGYGP exerted an additive effect on the amelioration of the biochemical indices of UV-induced photoaging skin. The histological changes showed that RPP and LSGYGP recovered the changes in skin tissue and endogenous collagen.
红毛丹果皮酚类物质（RPP）具有较高的抗氧化和抗炎活性。亮氨酸-丝氨酸-甘氨酸-酪氨酸-甘氨酸-脯氨酸（LSGYGP）具有良好的清除自由基活性和基质金属蛋白酶（MMPs）抑制能力。这些潜在机制表明，RPP 和 LSGYGP 可能用于抗光老化。关于 RPP 和 LSGYGP 对体内光老化影响的数据很少。我们评估了 RPP 和/或 LSGYGP 对紫外线（UV）诱导无毛小鼠皮肤光老化的影响。特别是，我们分析了 RPP 和 LSGYGP 的相加作用。小鼠皮肤的生化指标，包括组成（胶原蛋白和透明质酸[HA]含量）、氧化应激（抗氧化酶活性和谷胱甘肽和丙二醛含量）、MMPs（MMP-1、MMP-3 和 MMP-9 水平）、炎症细胞因子（白细胞介素（IL）-1α、肿瘤核因子-α和 IL-6 水平）和丝裂原激活蛋白激酶途径的磷酸化，都进行了分析。结果表明 RPP 和/或 LSGYGP 对光老化皮肤有保护作用。LSGYGP 对皮肤胶原蛋白和 HA 含量有显著作用。RPP 对调节氧化应激和炎症细胞因子水平有较好的效果。RPP 和 LSGYGP 对改善 UV 诱导光老化皮肤的生化指标具有相加作用。组织学变化表明，RPP 和 LSGYGP 恢复了皮肤组织和内源性胶原蛋白的变化。
