Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
Department of Biomedical Engineering of the Montescano Institute, Istituti Clinici Scientifici Maugeri IRCCS, 27040 Montescano, Italy.
Nutrients. 2021 May 13;13(5):1632. doi: 10.3390/nu13051632.
The goal of this retrospective study was to document any alterations in plasma amino acids (AAs) in subjects with cardiorenal syndrome type 2 (CRS 2). We analyzed data from sixteen patients with CRS 2 and eight healthy subjects (control group, C), whose plasma arterial (A) and venous (V) AA concentrations had been measured. Compared to C, the group of CRS 2 patients showed significant reductions by more than 90% in A ( < 0.01) and V ( < 0.01) individual AAs, whereas negative A-V differences that indicated a net muscle AA release (muscle hypercatabolism) were found in 59% of CRS 2 patients ( < 0.03). No significant differences in plasma A and V AA concentrations nor in A-V differences were found between patients with mild kidney damage ( = 5; estimated glomerular filtration rate, eGFR ≥ 60 mL/min/1.73 m) and patients with moderate-severe kidney damage ( = 11; eGFR < 60 mL/min/1.73 m). Several plasma arterial AAs correlated with hemodynamic variables, but not with GFR. The study showed that patients with CRS 2 had very low concentrations of circulating AAs, independent of the degree of GFR damage.
这项回顾性研究的目的是记录 2 型心肾综合征（CRS 2）患者血浆氨基酸（AA）的任何变化。我们分析了 16 例 CRS 2 患者和 8 例健康受试者（对照组，C）的数据，测量了他们的血浆动脉（A）和静脉（V）AA 浓度。与 C 相比，CRS 2 患者的 A（<0.01）和 V（<0.01）个体 AA 浓度显著降低了 90%以上，而 59%的 CRS 2 患者出现了负的 A-V 差异，表明存在肌肉 AA 净释放（肌肉高分解代谢）（<0.03）。在轻度肾功能损害的患者（=5；肾小球滤过率估计值，eGFR≥60 mL/min/1.73 m）和中度-重度肾功能损害的患者（=11；eGFR<60 mL/min/1.73 m）之间，血浆 A 和 V AA 浓度的差异或 A-V 差异均无显著差异。一些血浆动脉 AA 与血流动力学变量相关，但与 GFR 无关。研究表明，CRS 2 患者的循环 AA 浓度非常低，与 GFR 损害的程度无关。
