Șaramet Veaceslav, Meleșcanu-Imre Marina, Țâncu Ana Maria Cristina, Albu Crenguța Cristina, Ripszky-Totan Alexandra, Pantea Mihaela
Private Practice, 010221 Bucharest, Romania.
Department of Complete Denture, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 010221 Bucharest, Romania.
Materials (Basel). 2021 May 13;14(10):2537. doi: 10.3390/ma14102537.
Dentin and enamel loss related to trauma or especially caries is one of the most common pathological issues in dentistry that requires restoration of the teeth by using materials with appropriate properties. The composite resins represent dental materials with significant importance in today's dentistry, presenting important qualities, including their mechanical behavior and excellent aesthetics. This paper focuses on the saliva interactions with these materials and on their biocompatibility, which is continuously improved in the new generations of resin-based composites. Starting from the elements involved on the molecular landscape of the dental caries process, the paper presents certain strategies for obtaining more advanced new dental composite resins, as follows: suppression of oral biofilm acids formation, promotion of remineralization process, counteraction of the proteolytic attack, and avoidance of cytotoxic effects; the relation between dental composite resins and salivary oxidative stress biomarkers is also presented in this context.
与创伤尤其是龋齿相关的牙本质和牙釉质丧失是牙科领域最常见的病理问题之一，需要使用具有适当性能的材料对牙齿进行修复。复合树脂是当今牙科领域具有重要意义的牙科材料，具有重要特性，包括其机械性能和出色的美观性。本文重点关注唾液与这些材料的相互作用以及它们的生物相容性，新一代树脂基复合材料的生物相容性在不断提高。从龋齿过程分子层面涉及的因素出发，本文提出了获得更先进新型牙科复合树脂的某些策略，如下：抑制口腔生物膜酸的形成、促进再矿化过程、对抗蛋白水解攻击以及避免细胞毒性作用；在此背景下还介绍了牙科复合树脂与唾液氧化应激生物标志物之间的关系。
