Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Clinical Research Unit (CRU), Egas Moniz-Cooperativa de Ensino Superior, 2829-511 Caparica, Portugal.
Evidence-Based Hub, CRU, CiiEM, Egas Moniz-Cooperativa de Ensino Superior, 2829-511 Caparica, Portugal.
Int J Environ Res Public Health. 2021 May 10;18(9):5032. doi: 10.3390/ijerph18095032.
To evaluate tooth loss severity in PD patients and the impact of missing teeth on blood pressure (BP) and glycated hemoglobin (Hba1c) levels. All adults reporting specific PD medication regimens with complete dental examinations were included from the NHANES 2001 to 2018 databases. Sociodemographic, systolic BP (SBP), diastolic BP (DBP) and Hba1c data were compared according to tooth loss severity, and linear regression analyses on the impact of tooth loss on SBP, DBP and Hba1c levels were conducted. The 214 included participants presented 9.7 missing teeth, 23.8% severe tooth loss and 18.2% total edentulousness. Severe tooth loss cases were significantly older ( < 0.001), had higher smoking prevalence ( = 0.008), chronic medical conditions ( = 0.012) and higher Hba1c ( = 0.001), SBP ( = 0.015) and DBP ( < 0.001) levels. Crude and adjusted linear models revealed a relationship between SBP, DBP and missing teeth; however, age confounded these links (SBP: B = 0.10, SE = 0.16, < 0.05; DBP: B = 0.16, SE = 0.10, < 0.05). Tooth loss presented no significant relationship with Hba1c levels. Severe tooth loss is prevalent among PD patients. Blood pressure levels showed a positive linear relationship with the number of missing teeth, although age was a confounding factor. Furthermore, tooth loss and Hba1c levels revealed no significant linear relationship.
评估 PD 患者的牙齿缺失严重程度，以及缺牙对血压（BP）和糖化血红蛋白（HbA1c）水平的影响。从 NHANES 2001 年至 2018 年数据库中纳入报告特定 PD 药物治疗方案且有完整牙科检查的所有成年人。根据牙齿缺失严重程度比较社会人口统计学、收缩压（SBP）、舒张压（DBP）和 HbA1c 数据，并进行线性回归分析牙齿缺失对 SBP、DBP 和 HbA1c 水平的影响。214 名纳入的参与者缺失 9.7 颗牙齿，23.8%有严重牙齿缺失，18.2%完全无牙。严重牙齿缺失的病例年龄明显更大（<0.001），吸烟率更高（=0.008），慢性疾病更多（=0.012），HbA1c（=0.001）、SBP（=0.015）和 DBP（<0.001）水平更高。未校正和校正的线性模型显示 SBP、DBP 与缺失牙齿之间存在关系；然而，年龄混淆了这些联系（SBP：B=0.10，SE=0.16，<0.05；DBP：B=0.16，SE=0.10，<0.05）。牙齿缺失与 HbA1c 水平无显著关系。PD 患者中严重牙齿缺失很常见。尽管年龄是一个混杂因素，但血压水平与缺失牙齿数量呈正线性关系。此外，牙齿缺失与 HbA1c 水平之间无显著线性关系。
