Shin Dayeon, Lee Kyung-Won
Department of Food and Nutrition, Inha University, Incheon 22212, Korea.
Department of Home Economics Education, Korea National University of Education, Cheongju 28173, Korea.
J Pers Med. 2021 May 14;11(5):412. doi: 10.3390/jpm11050412.
The circadian locomotor output cycles kaput () gene plays a crucial role in regulating circadian rhythms through its transcription factor gene product. The objective of this study was to investigate the association between rs1801260 and the incidence of metabolic syndrome modulated by dietary monounsaturated fatty acid (MUFA) intake in Korean adults. Using a dataset from the Ansan-Ansung Cohort Study of the Korean Genome and Epidemiology Study, 3608 Korean adults were included after an average of nine years of follow-up. Men who were minor allele carriers (G allele) of rs1801260 had a 18% higher incidence of metabolic syndrome than non-carriers [hazard ratio (HR), 1.18; 95% confidence interval (CI), 1.00-1.40; Value = 0.047]. By dichotomizing dietary MUFA intake, we observed that men who were minor allele carriers (G allele) of rs1801260 had a 42% increased incidence of metabolic syndrome when dietary MUFA intake was ≤3.5% (HR: 1.42, 95% CI 1.23-1.81; Value = 0.004). No significant association was found between rs1801260 and the incidence of metabolic syndrome modulated by dietary MUFA intake in women. polymorphisms affected metabolic syndrome, modulated by dietary MUFA intake in men. These results suggest the significance of genes in the pathogenesis of metabolic syndrome and the modulating role of dietary MUFA intake and provide new insights into the underlying mechanisms connecting the circadian system, dietary factors, and metabolic syndrome.
昼夜运动输出周期失效（）基因通过其转录因子基因产物在调节昼夜节律中起关键作用。本研究的目的是调查韩国成年人中rs1801260与饮食中单不饱和脂肪酸（MUFA）摄入量调节的代谢综合征发病率之间的关联。使用韩国基因组与流行病学研究的安山 - 安城队列研究数据集，在平均九年的随访后纳入了3608名韩国成年人。rs1801260的次要等位基因携带者（G等位基因）男性患代谢综合征的发病率比非携带者高18％[风险比（HR），1.18；95％置信区间（CI），1.00 - 1.40；P值 = 0.047]。通过将饮食中MUFA摄入量二分法，我们观察到当饮食中MUFA摄入量≤3.5％时，rs1801260的次要等位基因携带者（G等位基因）男性患代谢综合征的发病率增加了42％（HR：1.42，95％CI 1.23 - 1.81；P值 = 0.004）。在女性中，未发现rs1801260与饮食中MUFA摄入量调节的代谢综合征发病率之间存在显著关联。基因多态性影响代谢综合征，受男性饮食中MUFA摄入量调节。这些结果表明基因在代谢综合征发病机制中的重要性以及饮食中MUFA摄入量的调节作用，并为连接昼夜节律系统、饮食因素和代谢综合征的潜在机制提供了新的见解。
