Scientific Research Institute of Human Morphology, 117418 Moscow, Russia.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I., Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.
Int J Mol Sci. 2021 May 14;22(10):5196. doi: 10.3390/ijms22105196.
Endometriosis and cancer have much in common, notably their burgeoning of cells in hypoxic milieus, their invasiveness, and their capacity to trigger remodeling, vascularization, and innervation of other tissues. An important role in these processes is played by permissive microenvironments inhabited by a variety of stromal and immune cells, including macrophages. Remarkable phenotypical plasticity of macrophages makes them a promising therapeutic target; some key issues are the range of macrophage phenotypes characteristic of a particular pathology and the possible manners of its modulation. In both endometriosis and cancer, macrophages guard the lesions from immune surveillance while promoting pathological cell growth, invasion, and metastasis. This review article focuses on a comparative analysis of macrophage behaviors in endometriosis and cancer. We also highlight recent reports on the experimental modulation of macrophage phenotypes in preclinical models of endometriosis and cancer.
子宫内膜异位症和癌症有许多共同之处，特别是它们在缺氧环境中细胞的过度生长、侵袭性以及触发其他组织重塑、血管生成和神经支配的能力。各种基质细胞和免疫细胞（包括巨噬细胞）居住的有利微环境在这些过程中起着重要作用。巨噬细胞显著的表型可塑性使它们成为有前途的治疗靶点；一些关键问题是特定病理学特征的巨噬细胞表型范围及其可能的调节方式。在子宫内膜异位症和癌症中，巨噬细胞保护病变免受免疫监视，同时促进病理性细胞生长、侵袭和转移。本文重点对子宫内膜异位症和癌症中巨噬细胞行为进行比较分析。我们还强调了最近关于在子宫内膜异位症和癌症的临床前模型中实验调节巨噬细胞表型的报告。
