Laboratório de Epidemiologia Molecular, Faculdade de Medicina Veterinária, Universidade Federal de Uberlândia, Uberlândia 38400-000, Brazil.
Laboratório de Epidemiologia Molecular, Instituto de Biologia, Universidade Federal de Uberlândia, Uberlândia 38400-000, Brazil.
Int J Environ Res Public Health. 2021 May 14;18(10):5245. doi: 10.3390/ijerph18105245.
COVID-19 is considered by the World Health Organization to be a global public health emergency, which presents regional divergences that affect the epidemiological profile of the disease and are associated with political, economic, social and behavioral aspects. We aimed to analyze the epidemiological characteristics of the disease in the microregion of Uberlândia, Brazil, in order to determine risk factors that contributed to progression of SARS-CoV-2 virus. A cross-sectional study was conducted about micro- and macro-determinants combined with the significance analysis of suspected and confirmed cases in 18 municipalities during the epidemiological weeks (EW) 9 to 26. There were 34,046 notifications, of which 4935 (14.49%) people were diagnosed with COVID-19. Of these, 282 (5.71%) required hospital care and 40 (0.81%) died. Age and presence of associated comorbidities were decisive in the variations of incidence and lethality rates. In general, young people were the most affected and the elderly people, the most exposed to the serious and lethal form ( < 0.0001). Comorbidities such as diabetes and cardiopathies increased 33.5 times the death risk. The dispersion of the virus was centrifugal, in the inter as well as in the intra-municipal level. The disorderly implementation of municipal decrees applied in a decentralized manner in the municipalities seems to have contributed for the incidence rates increasing in the EW 25 and 26.
世界卫生组织认为 COVID-19 是一场全球公共卫生紧急事件，它呈现出地区差异，影响着疾病的流行病学特征，并与政治、经济、社会和行为方面有关。我们旨在分析巴西 Uberlândia 微区的疾病流行病学特征，以确定导致 SARS-CoV-2 病毒进展的危险因素。在第 9 至 26 个流行病学周期间，对微区和大区决定因素进行了横断面研究，并结合了 18 个城市疑似和确诊病例的意义分析。共收到 34046 例通知，其中 4935 例（14.49%）被诊断为 COVID-19。其中，282 例（5.71%）需要住院治疗，40 例（0.81%）死亡。年龄和伴随的合并症在发病率和死亡率的变化中起决定性作用。一般来说，年轻人受影响最大，老年人则最容易出现严重和致命的形式（<0.0001）。糖尿病和心脏病等合并症使死亡风险增加了 33.5 倍。病毒的传播呈离心状，在城市之间和城市内部都有传播。在城市间以分散的方式实施的市政法令无序执行，似乎导致了第 25 和 26 个流行病学周发病率的上升。
