Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, Via Palatucci snc, University of Messina, 98168 Messina, Italy.
Unit of Animal Production, Department of Veterinary Sciences, Via Palatucci snc, Messina University, 98168 Messina, Italy.
Molecules. 2021 May 19;26(10):3014. doi: 10.3390/molecules26103014.
Obesity is a pathological condition, defined as an excessive accumulation of fat, primarily caused by an energy imbalance. The storage of excess energy in the form of triglycerides within the adipocyte leads to lipotoxicity and promotes the phenotypic switch in the M1/M2 macrophage. These changes induce the development of a chronic state of low-grade inflammation, subsequently generating obesity-related complications, commonly known as metabolic syndromes. Over the past decade, obesity has been studied in many animal models. However, due to its competitive aspects and unique characteristics, the use of zebrafish has begun to gain traction in experimental obesity research. To counteract obesity and its related comorbidities, several natural substances have been studied. One of those natural substances reported to have substantial biological effects on obesity are flavonoids. This review summarizes the results of studies that examined the effects of flavonoids on obesity and related diseases and the emergence of zebrafish as a model of diet-induced obesity.
肥胖是一种病理状态，定义为脂肪的过度积累，主要由能量失衡引起。多余的能量以三酸甘油脂的形式储存在脂肪细胞中，导致脂毒性，并促进 M1/M2 巨噬细胞的表型转换。这些变化诱导慢性低度炎症的发展，随后产生与肥胖相关的并发症，通常称为代谢综合征。在过去的十年中，许多动物模型都对肥胖进行了研究。然而，由于其竞争方面和独特的特点，使用斑马鱼开始在实验性肥胖研究中受到关注。为了对抗肥胖及其相关的合并症，已经研究了几种天然物质。其中一种被报道对肥胖具有实质性生物学作用的天然物质是类黄酮。本综述总结了研究类黄酮对肥胖和相关疾病的影响以及斑马鱼作为饮食诱导肥胖模型的出现的结果。
