Institute of Pharmacy, College of Pharmacy, Henan University, Kaifeng 475004, China; Kaifeng Key Lab for Application of Local Dendranthema morifolium in Food & Drug, Kaifeng 475004, China.
Institute of Pharmacy, College of Pharmacy, Henan University, Kaifeng 475004, China; Kaifeng Key Lab for Application of Local Dendranthema morifolium in Food & Drug, Kaifeng 475004, China.
Fitoterapia. 2019 Apr;134:39-43. doi: 10.1016/j.fitote.2019.02.003. Epub 2019 Feb 4.
Dendranthema morifolium cv. 'jinsidaju', cultivated only in Kaifeng, has been eaten for more than 1000 years. During the antioxidant-activity-guided studies on its chemistry and health care function, two new bisabolane-type sesquiterpenes, (6R,7R)-7-hydroxybisabol-2,9E,11-triene-4-one (jinsidajuol A, 1) and (6R,7R)-7-hydroxy-11-methoxybisabol-2,9E-diene-4-one (jinsidajuol B, 2), and thirteen known compounds (3-15) were isolated from the flowers. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRMS. 1 and 2 are the first example of bisabolane-type sesquiterpenes isolated from the genus Dendranthema. Compounds 6-8, 12 and 13 exhibited strong scavenging activities on the ABTS radical cation with IC 3.33, 5.67, 2.00, 2.50, 5.33 μg/mL, respectively. The IC values of all compounds on HepG2 human hepatoma tumor cell line were higher than 50 μM.
仅在开封种植的菊花（Dendranthema morifolium cv. 'jinsidaju'）已有超过 1000 年的食用历史。在对其化学成分和保健功能的抗氧化活性导向研究中，从花朵中分离得到了两种新的倍半萜类化合物（6R,7R）-7-羟基-二氢-大根香叶-2,9E,11-三烯-4-酮（jinsidajuol A，1）和（6R,7R）-7-羟基-11-甲氧基-二氢-大根香叶-2,9E-二烯-4-酮（jinsidajuol B，2），以及 13 种已知化合物（3-15）。通过 1D 和 2D NMR 光谱和 HRMS 确定了它们的结构。1 和 2 是首次从菊属植物中分离得到的倍半萜类化合物。化合物 6-8、12 和 13 对 ABTS 自由基阳离子具有很强的清除活性，IC 50 值分别为 3.33、5.67、2.00、2.50、5.33μg/mL。所有化合物对 HepG2 人肝癌肿瘤细胞系的 IC 值均高于 50μM。
