State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Phytochemistry. 2021 Dec;192:112927. doi: 10.1016/j.phytochem.2021.112927. Epub 2021 Sep 4.
Bisabolane-type sesquiterpenoids, a class of monocyclic sesquiterpenoids, are widely distributed in nature and have a variety of biological activities. To provide a reference for the further research and development of these compounds, the phytochemical and biological properties of natural bisabolane-type sesquiterpenoids (356 compounds in total) isolated between 1985 and 2020 from 24 families, primarily Compositae, Zingiberaceae, Aspergillaceae, Halichondriidae, and Aplysiidae were reviewed. In vitro and in vivo studies have indicated that antibacterial, anti-inflammatory, and cytotoxic effects are the most commonly reported pharmacological properties of bisabolane-type sesquiterpenoids. Owing to their extensive significant effects, a lot of traditional medicines containing this type of compounds have been used for a long history. Thus, bisabolane-type sesquiterpenoids are a rich source of important natural products, which show great potential for the development of new drugs.
双环倍半萜类化合物是一类单环倍半萜类化合物，广泛分布于自然界，具有多种生物活性。为了为这些化合物的进一步研究和开发提供参考，本文综述了 1985 年至 2020 年期间从 24 科（主要为菊科、姜科、曲霉菌科、珍珠贝科和海鞘科）分离得到的天然双环倍半萜类化合物（共 356 种）的植物化学和生物活性。体外和体内研究表明，双环倍半萜类化合物具有抗菌、抗炎和细胞毒性作用，是最常见的药理活性。由于其广泛的显著作用，许多含有此类化合物的传统药物已经使用了很长时间。因此，双环倍半萜类化合物是重要天然产物的丰富来源，具有开发新药的巨大潜力。
