Pagano Cristina, Navarra Giovanna, Gazzerro Patrizia, Vitale Mario, Notarnicola Maria, Caruso Maria Gabriella, Cavalcanti Elisabetta, Armentano Raffaele, Laezza Chiara, Bifulco Maurizio
Department of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", 80131 Naples, Italy.
Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy.
Diagnostics (Basel). 2021 May 18;11(5):896. doi: 10.3390/diagnostics11050896.
Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. We comparatively analyzed CRYAB protein expression in 111 CRC tissues and normal adjacent colonic tissue, observing that it was significantly lower in CRC tissues than in corresponding non-cancerous tissues. Moreover, immunohistochemical analysis showed a significant correlation between CRYAB expression and high histological grade G3 ( = 0.033). In summary, our results point to its possible application as a prognostic biomarker in CRC patients.
αB-晶状体蛋白（CRYAB，HSPB5）属于小热休克蛋白（HSP）家族，在多种人类癌症中高表达，提示其在肿瘤进展中起关键作用。然而，很少有研究检测CRYAB在结直肠癌（CRC）中的表达。在本研究中，我们调查了CRYAB表达与CRC样本临床病理特征之间的关系。我们比较分析了111例CRC组织和相邻正常结肠组织中CRYAB蛋白的表达，发现CRC组织中的表达明显低于相应的非癌组织。此外，免疫组化分析显示CRYAB表达与高组织学分级G3显著相关（ = 0.033）。总之，我们的结果表明其可能作为CRC患者的预后生物标志物。
