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CRYAB可预测结直肠癌的临床预后并与免疫细胞浸润相关。

CRYAB predicts clinical prognosis and is associated with immunocyte infiltration in colorectal cancer.

作者信息

Deng Junsheng, Chen Xiaoli, Zhan Ting, Chen Mengge, Yan Xisheng, Huang Xiaodong

机构信息

Gastroenterology, Tongren Hospital of Wuhan University, Wuhan, Hubei, China.

Tongren Hospital of Wuhan Unversity, Wuhan, Hubei, China.

出版信息

PeerJ. 2021 Dec 10;9:e12578. doi: 10.7717/peerj.12578. eCollection 2021.

DOI:10.7717/peerj.12578
PMID:34966587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8667716/
Abstract

BACKGROUND

αB-Crystallin (CRYAB) is differentially expressed in various tumors. However, the correlation between CRYAB and immune cell infiltration in colorectal cancer (CRC) remains unclear.

MATERIALS & METHODS: Kaplan-Meier survival curves in The Cancer Genome Atlas (TCGA) were used to evaluate the relationship between CRYAB expression and both overall survival and progression-free survival. The relationships between CRYAB expression and infiltrating immune cells and their corresponding gene marker sets were examined using the TIMER database.

RESULTS

The expression of CRYAB was lower in CRC tumor tissues than in normal tissues ( < 0.05). High CRYAB gene expression and high levels of CRYAB gene methylation were correlated with high-grade malignant tumors and more advanced tumor, nodes and metastasis (TNM) cancer stages. In addition, in colorectal cancer, there was a positive correlation between CRYAB expression and immune infiltrating cells including neutrophils, macrophages, CD8 + T cells, and CD4 + T cells, as well as immune-related genes including CD2, CD3D, and CD3E. Methylation sites such as cg13084335, cg15545878, cg13210534, and cg15318568 were positively correlated with low expression of CRYAB.

CONCLUSION

Because CRYAB likely plays an important role in immune cell infiltration, it may be a potential tumor-suppressor gene in CRC and a potential novel therapeutic target and predictive biomarker for colorectal cancer (CRC).

摘要

背景

αB-晶状体蛋白（CRYAB）在多种肿瘤中存在差异表达。然而，CRYAB与结直肠癌（CRC）中免疫细胞浸润之间的相关性仍不清楚。

材料与方法

利用癌症基因组图谱（TCGA）中的Kaplan-Meier生存曲线来评估CRYAB表达与总生存期和无进展生存期之间的关系。使用TIMER数据库检测CRYAB表达与浸润免疫细胞及其相应基因标志物集之间的关系。

结果

CRC肿瘤组织中CRYAB的表达低于正常组织（<0.05）。CRYAB基因高表达和高水平的CRYAB基因甲基化与高级别恶性肿瘤和更晚期的肿瘤、淋巴结和转移（TNM）癌症分期相关。此外，在结直肠癌中，CRYAB表达与包括中性粒细胞、巨噬细胞、CD8 + T细胞和CD4 + T细胞在内的免疫浸润细胞以及包括CD2、CD3D和CD3E在内的免疫相关基因之间存在正相关。诸如cg13084335、cg15545878、cg13210534和cg15318568等甲基化位点与CRYAB低表达呈正相关。

结论

由于CRYAB可能在免疫细胞浸润中起重要作用，它可能是CRC中的一个潜在肿瘤抑制基因，也是结直肠癌（CRC）的一个潜在新型治疗靶点和预测生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/c39050919112/peerj-09-12578-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/554595e9cca3/peerj-09-12578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/293297d8db17/peerj-09-12578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/cc03b355a6e1/peerj-09-12578-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/88a00facde23/peerj-09-12578-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/9d797e84c32c/peerj-09-12578-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/9a5937c03e10/peerj-09-12578-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/c39050919112/peerj-09-12578-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/554595e9cca3/peerj-09-12578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/293297d8db17/peerj-09-12578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/cc03b355a6e1/peerj-09-12578-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/88a00facde23/peerj-09-12578-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/9d797e84c32c/peerj-09-12578-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/9a5937c03e10/peerj-09-12578-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/8667716/c39050919112/peerj-09-12578-g007.jpg

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