来自茎皮的三萜类化合物可降低脂多糖刺激的巨噬细胞中的亚硝酸盐水平。
Triterpenoids from Stem Barks Reduce Nitrite Levels in LPS-Stimulated Macrophages.
作者信息
Sirignano Carmina, Nadembega Pascal, Poli Ferruccio, Romano Barbara, Lucariello Giuseppe, Rigano Daniela, Taglialatela-Scafati Orazio
机构信息
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
The UFR Life and Earth Sciences (UFR/SVT), University of Ouagadougou, Ouagadougou 848, Burkina Faso.
出版信息
Plants (Basel). 2021 May 18;10(5):1006. doi: 10.3390/plants10051006.
C. F. Gaertn is widely used in African traditional medicine as an anti-inflammatory remedy to treat rheumatism, gastric problems, diarrhea, and dysentery. The phytochemical investigation of the ethyl acetate extract of stem bark collected in Burkina Faso led to the isolation of eight known and two triterpenes undescribed to date ( and ), in the free alcohol form or as acetyl and cinnamyl ester derivatives. The stereostructures of the new compounds were elucidated using HR-ESIMS and 1D and 2D NMR data. The isolated compounds were evaluated for their inhibitory effect on nitrite levels on murine macrophages J774 stimulated with the lipopolysaccharide (LPS). Among all the compounds tested, lupeol cinnamate () and betulinic acid () showed a beneficial effect in reducing nitrite levels produced after LPS stimulation.
C. F. Gaertn在非洲传统医学中被广泛用作抗炎药物，用于治疗风湿病、胃部问题、腹泻和痢疾。对在布基纳法索采集的茎皮乙酸乙酯提取物进行的植物化学研究，导致分离出8种已知的三萜类化合物和2种迄今未描述的三萜类化合物（和），它们以游离醇形式或作为乙酰酯和肉桂酯衍生物存在。使用高分辨电喷雾电离质谱（HR-ESIMS）以及一维和二维核磁共振（NMR）数据阐明了新化合物的立体结构。对分离出的化合物进行了评估，以确定它们对脂多糖（LPS）刺激的小鼠巨噬细胞J774中亚硝酸盐水平的抑制作用。在所有测试的化合物中，肉桂酸羽扇豆醇酯（）和桦木酸（）在降低LPS刺激后产生的亚硝酸盐水平方面显示出有益效果。
Zotero 插件