富含坚果三萜的提取物可改善肥胖大鼠创伤后骨关节炎的炎症症状。
Nut Triterpene-Rich Extract Ameliorates Symptoms of Inflammation on Post-Traumatic Osteoarthritis in Obese Rats.
作者信息
Sudirman Sabri, Chen Chun-Kai, Long Bing-Ting, Chang Heng-Wei, Tsou David, Kong Zwe-Ling
机构信息
Department of Food Science, National Taiwan Ocean University, Keelung City 20224, Taiwan.
出版信息
J Pain Res. 2020 Jan 30;13:261-271. doi: 10.2147/JPR.S228766. eCollection 2020.
PURPOSE
To investigate the ameliorative effects of (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats.
METHODS
The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats were treated orally with three different doses of VP nut extract (111.6, 223.2, and 446.4 mg/kg) for 8 weeks.
RESULTS
The VP nut triterpene-rich extract decreased the level of triglycerides and increased high-density lipoprotein-cholesterol. The level of nitric oxide, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α decreased after treatment with VP nut triterpene-rich extract, especially in high-doses. The VP nut triterpene-rich extracts also alleviated swelling in the knee OA, weight-bearing difference, and suppressed cartilage degradation.
CONCLUSION
The nut triterpene-rich extract suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis with an obesity rat model. As such, nut triterpene-rich extract can be used as an alternative for osteoarthritis treatment.
目的
研究（VP）坚果提取物对高脂饮食（HFD）诱导的肥胖大鼠前交叉韧带横断术联合内侧半月板切除术（ACLT + MMx）诱导的骨关节炎（OA）的改善作用。
方法
在手术诱导OA前，大鼠用HFD喂养5周。大鼠口服三种不同剂量的VP坚果提取物（111.6、223.2和446.4 mg/kg），持续8周。
结果
富含VP坚果三萜的提取物降低了甘油三酯水平并增加了高密度脂蛋白胆固醇。用富含VP坚果三萜的提取物治疗后，一氧化氮、白细胞介素（IL）-1β、IL-6和肿瘤坏死因子-α水平降低，尤其是高剂量时。富含VP坚果三萜的提取物还减轻了膝OA的肿胀、负重差异，并抑制了软骨降解。
结论
富含坚果三萜的提取物抑制促炎介质，减轻肥胖大鼠模型骨关节炎中的软骨降解和疼痛。因此，富含坚果三萜的提取物可作为骨关节炎治疗的替代药物。
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