Braun Katharina, Mannewitz Anja, Bock Joerg, Kreitz Silke, Hess Andreas, Scheich Henning, Goldschmidt Jürgen
Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Center for Behavioral Brain Sciences, 39106 Magdeburg, Germany.
Brain Sci. 2021 May 18;11(5):659. doi: 10.3390/brainsci11050659.
Active avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identified, the aim of this study was to obtain an overall picture of the brain circuits that are involved in active avoidance learning. In order to obtain a longitudinal assessment of activation patterns in the brain of freely behaving rats during different stages of learning, we applied single-photon emission computed tomography (SPECT). We were able to identify distinct prefrontal cortical, sensory, and limbic circuits that were specifically recruited during the acquisition and retrieval phases of the two-way avoidance learning task.
主动回避学习是一种复杂的厌恶反馈学习形式，在人类和其他动物中，它对于积极应对不愉快、厌恶或危险情况至关重要。由于双向回避（TWA）学习所涉及的功能回路尚未完全明确，本研究的目的是全面了解参与主动回避学习的脑回路。为了纵向评估自由活动大鼠在学习不同阶段大脑中的激活模式，我们应用了单光子发射计算机断层扫描（SPECT）。我们能够识别出在双向回避学习任务的获取和检索阶段被特异性激活的不同前额叶皮质、感觉和边缘回路。
