Antibacterial Polyketides Isolated from the Marine-Derived Fungus 8388.

Seven new polyketides named fusarisolins F-K (-) and fusarin I () were isolated from the marine-derived fungus 8388, together with the known anhydrojavanicin (), 5-deoxybostry coidin (), and scytalol A (). Their structures were established by comprehensive spectroscopic data analyses, and by comparison of the H and C NMR data with those reported in literature. Fusarisolin F () contained both a dichlorobenzene group and an ethylene oxide unit, which was rare in nature. In the bioassays, fusarisolin I (), fusarisolin J (), and 5-deoxybostry coidin () exhibited obvious antibacterial activities against methicillin-resistant n315 with MIC values of 3, 3, and 6 μg/mL, respectively. Fusarisolin H () and fusarisolin J () showed inhibitory effects against methicillin-resistant NCTC 10442 with the same MIC value of 6 μg/mL. With the exception of , all other compounds did not show or showed weak cytotoxicities against HeLa, A549, and KB cells; while fusarisolin J () demonstrated moderate cytotoxicities against the three human cancer cell lines with CC values between 9.21 and 14.02 μM.