Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44100 Ferrara, Italy.
Molecules. 2021 May 28;26(11):3255. doi: 10.3390/molecules26113255.
Deferoxamine B is an outstanding molecule which has been widely studied in the past decade for its ability to bind iron and many other metal ions. The versatility of this metal chelator makes it suitable for a number of medicinal and analytical applications, from the well-known iron chelation therapy to the most recent use in sensor devices. The three bidentate hydroxamic functional groups of deferoxamine B are the centerpiece of its metal binding ability, which allows the formation of stable complexes with many transition, lanthanoid and actinoid metal ions. In addition to the ferric ion, in fact, more than 20 different metal complexes of deferoxamine b have been characterized in terms of their chemical speciation in solution. In addition, the availability of a terminal amino group, most often not involved in complexation, opens the way to deferoxamine B modification and functionalization. This review aims to collect and summarize the available data concerning the complex-formation equilibria in solutions of deferoxamine B with different metal ions. A general overview of the progress of its applications over the past decade is also discussed, including the treatment of iron overload-associated diseases, its clinical use against cancer and neurodegenerative disorders and its role as a diagnostic tool.
去铁胺 B 是一种出色的分子，在过去十年中，因其能够结合铁和许多其他金属离子而得到了广泛的研究。这种金属螯合剂的多功能性使其适用于许多医学和分析应用，从众所周知的铁螯合疗法到最近在传感器设备中的应用。去铁胺 B 的三个双齿羟肟官能团是其金属结合能力的核心，使它能够与许多过渡金属、镧系元素和锕系元素金属离子形成稳定的配合物。除了三价铁离子，实际上，已经在溶液中对去铁胺 B 与 20 多种不同金属的配合物进行了化学形态分析。此外，由于末端氨基的存在，大多数情况下不参与配位，这为去铁胺 B 的修饰和功能化开辟了道路。本文旨在收集和总结有关去铁胺 B 与不同金属离子在溶液中形成配合物平衡的现有数据。还讨论了过去十年中其应用的进展概况，包括治疗铁过载相关疾病、临床用于癌症和神经退行性疾病以及作为诊断工具的用途。
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