Lu Lantian, Duong Viet Tram, Shalash Ahmed O, Skwarczynski Mariusz, Toth Istvan
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
Vaccines (Basel). 2021 May 28;9(6):563. doi: 10.3390/vaccines9060563.
The production of subunit nanovaccines relies heavily on the development of a vaccine delivery system that is safe and efficient at delivering antigens to the target site. Nanoparticles have been extensively investigated for vaccine delivery over the years, as they often possess self-adjuvanting properties. The conjugation of antigens to nanoparticles by covalent bonds ensures co-delivery of these components to the same subset of immune cells in order to trigger the desired immune responses. Herein, we review covalent conjugation strategies for grafting protein or peptide antigens onto other molecules or nanoparticles to obtain subunit nanovaccines. We also discuss the advantages of chemical conjugation in developing these vaccines.
亚单位纳米疫苗的生产在很大程度上依赖于疫苗递送系统的开发，该系统需能安全有效地将抗原递送至靶位点。多年来，纳米颗粒已被广泛研究用于疫苗递送，因为它们通常具有自我佐剂特性。通过共价键将抗原与纳米颗粒偶联，可确保这些成分共同递送至同一亚群的免疫细胞，从而触发所需的免疫反应。在此，我们综述了将蛋白质或肽抗原接枝到其他分子或纳米颗粒上以获得亚单位纳米疫苗的共价偶联策略。我们还讨论了化学偶联在开发这些疫苗中的优势。
