藻酸盐和/或四环素对磷酸钙骨水泥性能的影响。
Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties.
机构信息
Biomaterials Center, University of Havana, La Habana 10400, Cuba.
Translational Nanobiomaterials and Imaging Group, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
出版信息
Molecules. 2021 May 28;26(11):3272. doi: 10.3390/molecules26113272.
Calcium phosphate cements have the advantage that they can be prepared as a paste that sets in a few minutes and can be easily adapted to the shape of the bone defect, which facilitates its clinical application. In this research, six formulations of brushite (dicalcium phosphate dihydrated) cement were obtained and the effect of the addition of sodium alginate was analyzed, such as its capacity as a tetracycline release system. The samples that contain sodium alginate set in 4 or 5 min and showed a high percentage of injectability (93%). The cements exhibit compression resistance values between 1.6 and 2.6 MPa. The drug was released in a range between 12.6 and 13.2% after 7 days. The antimicrobial activity of all the cements containing antibiotics was proven. All samples reached values of cell viability above 70 percent. We also observed that the addition of the sodium alginate and tetracycline improved the cell viability.
磷酸钙骨水泥的优势在于可以制备成糊剂，在几分钟内凝固，并且可以很容易地适应骨缺损的形状，这有利于其临床应用。在这项研究中，得到了六种羟磷灰石（二水合磷酸二钙）水泥的配方，并分析了藻酸钠的添加效果，例如其作为四环素释放系统的能力。含有藻酸钠的样品在 4 到 5 分钟内凝固，并显示出高的可注射性（93%）。水泥的抗压强度值在 1.6 到 2.6 MPa 之间。在 7 天后，药物释放量在 12.6%到 13.2%之间。所有含有抗生素的水泥的抗菌活性都得到了证明。所有样品的细胞活力都达到了 70%以上。我们还观察到，藻酸钠和四环素的添加提高了细胞活力。
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