Alves Hugo Leonardo Rocha, Dos Santos Luis A, Bergmann Carlos P
Department of Materials Science and Engineering, Federal University of Rio Grande do Sul, Avenida Osvaldo Aranha, 99, 705c, Centro, Porto Alegre, RS 90620-000, Brazil.
J Mater Sci Mater Med. 2008 May;19(5):2241-6. doi: 10.1007/s10856-007-3329-6. Epub 2007 Dec 1.
Calcium phosphate cements are biomaterials made from a mixture of calcium phosphate powder in aqueous solutions that forms a paste that reacts at the body temperature and hardens as a result of precipitation reactions. These cements are commonly used in dentistry and orthopedic bone filling surgeries, which require extremely invasive procedures. The challenge consists in formulating an injectable paste by additives incorporation. In this work, three different additives (carboxymethylcellulose, agar polymer and sodium alginate) were incorporated to tricalcium phosphate, in concentrations of 0.4, 0.8, 1.6, 3.2 and 6.4 wt.%. Injectability was evaluated through a new method developed for this purpose. Results showed that it was possible to obtain injectable compositions of alpha-tricalcium phosphate cement. It was verified that the injectability depends on the rheological behavior of the pastes and injection time. In this study, pastes with viscosity suitable for good homogenization and injection were obtained.
磷酸钙骨水泥是由磷酸钙粉末在水溶液中混合而成的生物材料，形成一种糊状物，该糊状物在体温下发生反应，并由于沉淀反应而硬化。这些骨水泥通常用于牙科和骨科骨填充手术，而这些手术需要极其侵入性的操作。挑战在于通过添加添加剂来配制可注射的糊剂。在这项工作中，将三种不同的添加剂（羧甲基纤维素、琼脂聚合物和海藻酸钠）以0.4、0.8、1.6、3.2和6.4 wt.%的浓度加入到磷酸三钙中。通过为此目的开发的一种新方法评估了可注射性。结果表明，可以获得α-磷酸三钙骨水泥的可注射组合物。证实了可注射性取决于糊剂的流变行为和注射时间。在本研究中，获得了具有适合良好均匀化和注射的粘度的糊剂。
